The Plasticity of CD4CD25FOXP3CD127 T Cells in Patients with Metastatic Renal Cell Carcinoma in the Course of Interferon-Alpha Immunotherapy.

Aims: To examine changes in subpopulation of CD4CD25Foxp3CD127 T lymphocytes (Treg) and their association with the efficiency of the IFN- therapy.

Materials And Methods: Pts with mRCC who had undergone nephrectomy were treated with IFN- at a dose of 6 × 10 U/day three times a week ( = 18). An immunophenotypic analysis of lymphocytes in peripheral blood expressing CD4, CD25, CD127, and Foxp3 antigens could be performed in 18 pts before, 2 weeks, and 2 mo after IFN- therapy and 22 normal volunteers.

Complex Monitoring of Biochemical and Radionuclide Parameters in Patients with Metastatic Renal Cell Carcinoma during Immunotherapy.

Study Objective: To study the effectiveness of complex monitoring of the kidney function, based on biochemical and radionuclide methods in patients with metastatic renal cell carcinoma (mRCC).

Materials And Methods: 41 mRCC patients after nephrectomy received nivolumab ( = 23) and interferon- ( = 18) from 2015 to 2017. At baseline and 2 months after, all patients underwent blood chemistry, urinalysis, Rehberg test, and ELISA to determine serum levels of IL-17A, TGF-, and erythropoietin.

Nuclear Protein of the Testis Midline Carcinoma Masquerading as a Primary Mediastinal Seminoma.

Nuclear protein of the testis (NUT) midline carcinomas are rare aggressive carcinomas characterized by chromosomal rearrangements that involve the gene encoding the NUT. This article reviews the clinicopathologic features and the differential diagnosis of these malignancies.

Effects of deafferentation on the size and myosin phenotype of muscle fibers on stretching of the rat soleus muscle in conditions of gravitational unloading.

The aim of the present work was to assess the contributions of the reflex and local components to preventing decreases in the size and changes in the ratio of fibers containing the slow and fast isoforms of myosin heavy chains during chronic stretching of a postural muscle in rats in conditions of gravitational unloading. A unilateral surgical deafferentation method was used. The results demonstrated that deafferentation of the hindlimb had no effect on preventing reductions in muscle fiber size in conditions of chronic muscle stretching in conditions of gravitational unloading.

Role of afferent control in maintaining structural and metabolic characteristics of stretched soleus in rats exposed to hindlimb suspension.

It is known that gravitational unloading (GU) induces atrophy of skeletal muscles and slow-to-fast muscle fiber (MF) transformation. Stretching of m. soleus prevents those changes, probably afferent information from the stretched muscle acting as triggering mechanism.