Publications by authors named "Sayanti Dey"
Our understanding of the C-type lectin-like receptors (CTLRs) and their functions in immunity have continued to expand from their initial roles in pathogen recognition. There are now clear examples of CTLRs acting as scavenger receptors, sensors of cell death and cell transformation, and regulators of immune responses and homeostasis. This range of function reflects an extensive diversity in the expression and signaling activity between individual CTLR members of otherwise highly conserved families.
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- Alveolar macrophages (AM) are crucial for lung health, fighting pathogens and regulating surfactant to prevent lung diseases.
- The NK cell receptor NKR-P1B is vital for the metabolic functions of AM, and its absence leads to weakened immune responses and lipid accumulation in AM.
- A specific communication pathway between AM and alveolar type-II cells, dependent on Clr-g, is key for maintaining AM metabolism and overall lung function.
Article Synopsis
- Influenza A virus (IAV) enhances the presentation of class I human leukocyte antigen (HLA) proteins on lung epithelial cells, which helps the virus evade attacks from natural killer (NK) cells.
- Infection with IAV leads to HLA upregulation in a process dependent on mini viral RNAs (mvRNAs) and defective interfering RNAs (DI RNAs) rather than just the viral entry.
- The nonstructural 1 (NS1) protein of the virus acts to regulate and limit this HLA upregulation, potentially balancing the virus's ability to evade the immune response with control mechanisms.