Publications by authors named "Sayanti Acharyya"
Article Synopsis
- * Research shows that air pollutants disrupt protective mechanisms, trigger neuroinflammation, and cause harmful changes at the epigenetic level, particularly affecting the mitochondrial epigenome.
- * There is potential for using circulating epigenetic markers (like methylated DNA and miRNAs) as diagnostic tools and therapeutic targets, which may lead to improved diagnosis and treatment strategies through advanced technologies like AI and multi-omics.
Prenatal exposure to air pollution is a significant risk factor for the mother and the developing foetus. The accumulation of pollutants in the placenta can cause a self-cascade loop of pro-inflammatory cytokine responses and DNA double-strand breaks. Previous research has shown that airborne particulate matter can damage the epigenome and disturb mitochondrial machinery, ultimately impairing placental function.
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