Low-valent germanium and tin hydrides as catalysts for hydroboration, hydrodeoxygenation (HDO), and hydrodesulfurization (HDS) of heterocumulenes.

The low-valent germanium and tin hydrides, [LMH; L = {(ArHN)(ArN)-CN-C(NAr)(NHAr); Ar = 2,6-Et-CH}; M = Ge; (Ge-1), Sn (Sn-2)] bearing bis-guanidinato anions are employed as catalysts for chemoselective reduction of heterocumulenes hydroboration reactions. This protocol demonstrates that a wide range of carbodiimides (CDI), isocyanates, isothiocyanates, and isoselenocyanates undergo partial reduction, yielding the corresponding -boryl formamidine, -boryl formamide, -boryl thioformamide, and -boryl selenoformamide products, respectively. Isocyanates and isothiocyanates are further converted into -boryl methyl amines through hydrodeoxygenation (HDO) and hydrodesulfurization (HDS) reactions in the presence of catalyst Ge-1.

Formulation and characterization of polymeric nanoparticle of Rivastigmine for effective management of Alzheimer's disease.

Memory loss or dementia is a progressive disorder, and one of its common forms is Alzheimer's disease (AD), effecting mostly middle aged and older adults. In the present study, we developed Rivastigmine (RIV) nanoparticles using poly(lactic-co-glycolic acid) (RIV-loaded PLGA NPs) and polyvinyl alcohol (PVA). The prepared RIV-PLGA nanoparticles was evaluated for the management of Alzheimer's disease (AD).