Optimization of sandstone processing waste, electric arc furnace slag, and fly ash-based ternary blended eco-friendly geopolymers.

Over the years, ordinary Portland cement (OPC) has been used to meet growing demands of land and housing facilities arising out of population overburdens. It is well documented that OPCs, besides their outstanding qualities as building materials, are also significant contributors to global greenhouse gases (GHG). Consequently, recent years have noticed an emerging interest in the search for alternatives to Portland cement-based binders.

Assessing the impact of the National Clean Air Programme in Uttar Pradesh's non-attainment cities: a prophet model time series analysis.

Background: Uttar Pradesh, India's largest state, faces critical pollution levels, necessitating urgent action. The National Clean Air Programme (NCAP) targets a 40% reduction in particulate pollution by 2026. This study assesses the impact of NCAP on 15 non-attainment cities in Uttar Pradesh using the Prophet forecasting model.

Influence of activator ratios and concentration on the physio-mechanical and microstructural characteristics of the geopolymers derived from sandstone processing waste.

Natural stones have been utilized to meet various needs of human civilization since ancient times. The exploitation of any resource is associated with the production of redundant materials called wastes. Sandstone waste (SW) is one such waste obtained during the industrial processing of sandstones.

Hypertension: A National Cross-Sectional Study in India.

Objective: Hypertension is a global public health problem. This article aimed to estimate the national prevalence of hypertension in India for both women and men. The study had also examined the demographic and socioeconomic status of hypertensive women and men.

Violence against physicians and nurses: a systematic literature review.

Background: Violence against physicians and nurses is a global public health problem. This study explored violence against physicians and nurses using a systematic literature review.

Methods: Pubmed and Scopus were searched using search words 'violence' OR 'aggression' 'against' 'physicians' AND 'nurses'.

ApoE ε4 and IL-6-174G/C Polymorphism may Lead to Early Onset of Alzheimer's Disease with Atypical Presentation.

Background: Alzheimer's disease (AD) is the most common cause of dementia. Although genetic mutations are known in rare familial form, exact cause of neurodegeneration in sporadic AD is still unknown. While ApoE ε4 and IL-6 C-174G/C patterns have been found to increase the risk of AD in Caucasians, the results are inconsistent in other ethnic groups.

Midbrain infarction in inherited protein S deficiency: a rare association.

Inherited thrombophilic disorders are well-established predisposing factors for venous thromboembolism, but their role in arterial ischaemic stroke is uncertain. The exact mechanism of arterial thrombosis in thrombophilias remains elusive. Herein, we report a case of a 30-year-old woman who was admitted to our facility with sudden-onset right-sided ptosis and ophthalmoplegia.

Hedgehog dysregulation contributes to tissue-specific inflammaging of resident macrophages.

Age-associated low-grade sterile inflammation, commonly referred to as inflammaging, is a recognized hallmark of aging, which contributes to many age-related diseases. While tissue-resident macrophages are innate immune cells that secrete many types of inflammatory cytokines in response to various stimuli, it is not clear whether they have a role in driving inflammaging. Here we characterized the transcriptional changes associated with physiological aging in mouse resident macrophage populations across different tissues and sexes.

Assaying Homodimers of NF-κB in Live Single Cells.

NF-κB is a family of heterodimers and homodimers which are generated from subunits encoded by five genes. The predominant classical dimer RelA:p50 is presumed to operate as "NF-κB" in many contexts. However, there are several other dimer species which exist and may even be more functionally relevant in specific cell types.

Ezh2 Regulates Activation-Induced CD8 T Cell Cycle Progression Repressing and Expression.

Transition from resting to cell cycle in response to antigenic stimulation is an essential step for naïve CD8 T cells to differentiate to effector and memory cells. Leaving the resting state requires dramatic changes of chromatin status in the key cell cycle inhibitors but the details of these concerted events are not fully elucidated. Here, we showed that Ezh2, an enzymatic component of polycomb repressive complex 2 (PRC2) catalyzing the trimethylation of lysine 27 on histone 3 (H3K27me3), regulates activation induced naïve CD8 T cells proliferation and apoptosis.

Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential.

Components of the conserved engulfment pathways promote programmed cell death in Caenorhabditis elegans (C. elegans) through an unknown mechanism. Here we report that the phagocytic receptor CED-1 mEGF10 is required for the formation of a dorsal-ventral gradient of CED-3 caspase activity within the mother of a cell programmed to die and an increase in the level of CED-3 protein within its dying daughter.