Publications by authors named "Sayan Paul"

Stem cell research is a dynamic and fast-advancing discipline with great promise for the treatment of diverse human disorders. The incorporation of gene editing technologies, including ZFNs, TALENs, and the CRISPR/Cas system, in conjunction with progress in nanotechnology, is fundamentally transforming stem cell therapy and research. These innovations not only provide a glimmer of optimism for patients and healthcare practitioners but also possess the capacity to radically reshape medical treatment paradigms.

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Dinitrogen fixation through the Nitrogen Reduction Reaction (NRR) under mild conditions without the use of sacrificial agents has its share of formidable hurdles. It has been shown recently that Ru-doped Au nanoclusters can reduce N molecules to NH only in the presence of UV-Vis light in aqueous medium. Herein, using theoretical techniques (Density Functional Theory), we shed light on the mechanistic avenues traversed to achieve this prodigious chemical feat.

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Sleep is a universally conserved behavior whose origin and evolutionary purpose are uncertain. Using phylogenomics, this article investigates the evolutionary foundations of sleep from a never before used perspective. More specifically, it identifies orthologs of human sleep-related genes in the Lokiarchaeota of the Asgard superphylum and examines their functional role.

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Rhythmicity is a characteristic feature of the inanimate universe. The organization of biological rhythms in time is an adaptation to the cyclical environmental changes brought on by the earth's rotation on its axis and around the sun. Circadian (L.

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Developing thermally activated delayed fluorescence (TADF)-active silver clusters with near-unity quantum efficiency is of practical importance in cutting-edge optoelectronic devices, but remains a tremendous challenge due to the difficulty of de novo synthesis and uncertainty of properties. Herein, we demonstrate a lattice modulation on parent TADF- active silver cluster, achieving TADF-driven photoluminescence quantum yield (PLQY) from 12 % to near-unity. Systematic experimental and calculated results reveal that the lattice modulation effectively lowers the singlet-triplet splitting (ΔE) from 718 to 549 cm, thereby facilitating thermally activated reverse intersystem crossing: T→S, leading to extremely efficient TADF by surpassing both phosphorescence and non-radiative decay, thus boosting the near-unity PLQY.

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Whether it involves human subjects or non-human animals, basic, translational, or clinical sleep research poses significant ethical challenges for researchers and ethical committees alike. Sleep research greatly benefits from using diverse animal models, each offering unique insights into sleep control mechanisms. The fruit fly (Drosophila melanogaster) is a superior genetic model due to its quick generation period, large progenies, and rich genetic tools.

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Article Synopsis
  • This article discusses the total synthesis of specific naturally occurring isocoumarins, including 2'-methoxydihydroartemidin and ()-3'-hydroxyartemidin, using a unique method.
  • The synthesis involves an efficient and selective cyclization process of 2-halobenzoic acids and chiral terminal alkynes, facilitated by ligand-free Cu(I) catalysis.
  • The research includes in-depth mechanistic studies, revealing that the solvent plays a crucial role in directing the reaction pathway, leading to the successful synthesis of various small molecular entities from the isocoumarins.
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Cardiovascular disease (CVD) is associated with both genetic variants and environmental factors. One unifying consequence of the molecular risk factors in CVD is DNA damage, which must be repaired by DNA damage response proteins. However, the impact of DNA damage on global cardiomyocyte protein abundance, and its relationship to CVD risk remains unclear.

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  • Photocontrolled deprotection of functional groups is gaining traction, especially using specific wavelengths to achieve selective deprotection.
  • Researchers developed a new monochromophoric system based on a hydroxanthene moiety that can release two different functionalities when exposed to 450 nm and 600 nm light.
  • The study utilized various spectroscopy methods to analyze the photodegradation mechanism, revealing different electron transfer processes at each wavelength and showcasing potential applications in designing advanced photoreactive systems for materials.
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  • Understanding the importance of chemical bonding and atom dynamics is key to revealing how to achieve low thermal conductivity (κ) in crystalline materials, which is vital for applications like thermoelectrics.
  • Pauling's third empirical rule highlights cationic repulsion in crystal structures that can lead to lattice instability, as demonstrated in the ternary selenide TlAgSe, where ultra-low κ of 0.17 W/m.K at 573 K was achieved.
  • The study utilizes synchrotron X-ray pair distribution function analysis and density functional theory to show that Ag-Ag repulsion causes lattice instability, confirming the rule’s relevance and suggesting dynamic distortion as a strategy to lower thermal conductivity in crystals.
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  • Targeted treatments for breast cancer aim to minimize harm to healthy cells, and this study investigates riboflavin as a light-activated anticancer compound.
  • Using advanced calculations, researchers discovered that riboflavin transfers electronic charges from DNA, with significant activation under visible light.
  • Experiments on breast cancer cell lines showed that riboflavin effectively inhibited cell growth when exposed to light, while sparing normal cells, indicating its potential as a selective anticancer agent.
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Sleep genetics is an intriguing, as yet less understood, understudied, emerging area of biological and medical discipline. A generalist may not be aware of the current status of the field given the variety of journals that have published studies on the genetics of sleep and the circadian clock over the years. For researchers venturing into this fascinating area, this review thus includes fundamental features of circadian rhythm and genetic variables impacting sleep-wake cycles.

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Cancer is one of the leading causes of death worldwide and it is estimated that the mortality rate of cancer will increase in the coming years. The etiology of the development and progression of cancer is multifactorial. Insights have been gained on the association between the human microbiome and tumor cell malignancy.

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Enterococcus sp. emerged as an opportunistic nosocomial pathogen with the highest antibiotic resistance and mortality rate. Biofilm is problematic primarily since it is regulated by the global bacterial cell to cell communication mediated by the quorum sensing signaling system.

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In light of the recent surge in computational studies of gold thiolate clusters, we present a comparison of popular density functionals (DFAs) and three-part corrected methods (3c-methods) on their performance by taking a data set named as consisting of 18 isomers of Au(SCH) ( ≤ = 1-3). We have compared the efficiency and accuracy of the DFAs and 3c-methods in geometry optimization with RI-SCS-MP2 as the reference method. Similarly, the performance for accurate and efficient energy evaluation was compared with DLPNO-CCSD(T) as the reference method.

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Systemic sclerosis is a fibrotic disease that initiates in the skin and progresses to internal organs, leading to a poor prognosis. Unraveling the etiology of a chronic, multifactorial disease such as systemic sclerosis has been aided by various animal models that recapitulate certain aspects of the human pathology. We found that the transcription factor SNAI1 is overexpressed in the epidermis of patients with systemic sclerosis, and a transgenic mouse recapitulating this expression pattern is sufficient to induce many clinical features of the human disease.

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Cancer is a complex disease affecting millions of people around the world. Despite advances in surgical and radiation therapy, chemotherapy continues to be an important therapeutic option for the treatment of cancer. The current treatment is expensive and has several side effects.

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Among the annelids, earthworms are renowned for their phenomenal ability to regenerate the lost segments. The adult earthworm Eudrilus eugeniae contains 120 segments and the body segments of the earthworm are divided into pre-clitellar, clitellar and post-clitellar segments. The present study denoted that clitellum plays vital role in the successful regeneration of the species.

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Background: The arrestin domain containing proteins (ARRDCs) are crucial adaptor proteins assist in signal transduction and regulation of sensory physiology. The molecular localization of the ARRDC gene has been confined mainly to the mammalian system while in invertebrates the expression pattern was not addressed significantly. The present study reports the identification, tissue specific expression and functional characterization of an ARRDC transcript in earthworm, Eudrilus eugeniae.

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Background: Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease with preserved or increased ejection fraction in the absence of secondary causes. Mutations in the sarcomeric protein-encoding genes predominantly cause HCM. However, relatively little is known about the genetic impact of signalling proteins on HCM.

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  • The study investigates the impact of cadmium (Cd) and polychlorinated biphenyls (PCBs) on the growth of the Tagetes patula L. plant, revealing that a minimum concentration of PCBs can enhance plant biomass by nearly 28%.
  • In tests, Cd levels in plant tissues exceeded 100 mg/kg, showing a significant positive relationship between Cd and PCB accumulation in both soil and plants.
  • T. patula demonstrated a high tolerance to both pollutants and effectively removed up to 42% of specific PCBs, underscoring its potential for use in cleaning contaminated soils.
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Cardiac glycosides are natural sterols and constitute a group of secondary metabolites isolated from plants and animals. These cardiotonic agents are well recognized and accepted in the treatment of various cardiac diseases as they can increase the rate of cardiac contractions by acting on the cellular sodium potassium ATPase pump. However, a growing number of recent efforts were focused on exploring the antitumor and antiviral potential of these compounds.

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Context: This research describe the characteristic volume expansion of a moving target as a function of differential margins.

Aim: We aimed to ascertain the volume change after giving margin for clinical and set up uncertainties including generating internal target volume (ITV) for moving target.

Materials And Methods: Settings and Design - Spheres of diameter (0.

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WNT/β-catenin signaling orchestrates various physiological processes, including embryonic development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin signaling is associated with various cancers and its inhibition has shown effective antitumor responses. In this review, we discuss the pathway, potential targets for the development of WNT/β-catenin inhibitors, available inhibitors, and their specific molecular interactions with the target proteins.

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The oligochaete earthworm, Eudrilus eugeniae is capable of regenerating both anterior and posterior segments. The present study focuses on the transcriptome analysis of earthworm E. eugeniae to identify and functionally annotate the key genes supporting the anterior blastema formation and regulating the anterior regeneration of the worm.

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