Optimization of Chondrocyte Viability in Partially Decellularized Tracheal Grafts.

Objective: Advancements in tissue-engineered tracheal replacement (TETR) show promise for the use of partially decellularized tracheal grafts (PDTG) to address critical gaps in airway management and reconstruction. In this study, aiming to leverage the immunoprivileged nature of cartilage to preserve tracheal biomechanics, we optimize PDTG for retention of native chondrocytes.

Study Design: Comparison in vivo murine study.