Publications by authors named "Sayako Watanabe"
Background: Intraocular lens (IOL) fixation is performed after intraoperative anterior or total vitrectomy. This study aimed to compare the intraoperative and postoperative complications of these two techniques.
Methods: This retrospective study included 235 eyes that underwent intrascleral fixation surgery at our hospital between July 2014 and January 2021.
Article Synopsis
- Short half-lives and poor blood-brain barrier transport limit the effectiveness of cytokines and growth factors as receptor agonists.
- A new method called 'lasso-grafting' was used to genetically engineer macrocyclic peptide pharmacophores into the Fc region of human immunoglobulins, improving their stability and transport to the brain.
- These engineered proteins successfully mimicked the effects of natural ligand-induced biological responses and showed enhanced brain accumulation in experimental models, suggesting potential for improved protein therapeutics.