Type 2 inositol 1,4,5-trisphosphate receptor is predominantly involved in agonist-induced Ca(2+) signaling in Bergmann glia.

Ca(2+) release via inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) plays a crucial role in astrocyte functions such as modulation of neuronal activity and regulation of local blood flow in the cerebral cortex and hippocampus. Bergmann glia are unipolar cerebellar astrocytes that release Ca(2+) through IP(3)Rs in response to the activation of G(q)-coupled receptors. The composition of the three subtypes of IP(3)R is a factor that determines the spatiotemporal pattern of Ca(2+) release.