Publications by authors named "Sayaka Toyoshi"
Article Synopsis
- * Initial examinations revealed advanced cancer (stage IVA) with a tumor in the left lung, and she underwent chemotherapy and radiation therapy while showing signs of cardiac issues through ECG and imaging.
- * The patient suffered from recurring ventricular tachycardia that did not respond well to antiarrhythmic drugs, and despite some temporary relief, she passed away four months after the metastasis diagnosis, highlighting the need for early detection and treatment of such heart complications.
Article Synopsis
- Antibodies targeting the PD-1 receptor on T cells, like nivolumab, are now used to treat lung cancer but come with risks of immune-related side effects.
- A case study of a 77-year-old man illustrates that nivolumab can induce thrombocytopenia (low platelet count) after mild fever, despite no signs of serious underlying conditions.
- Treatment with prednisolone successfully restored platelet counts and led to tumor shrinkage, emphasizing the need for awareness of rare side effects associated with immune checkpoint inhibitors.
Background: Carboplatin (CBDCA) is known to exhibit a high emetic risk among moderate-emetic risk anticancer drugs, and the dose of CBDCA varies in different therapies. In concurrent chemoradiotherapy (CCRT) for non-small cell lung cancer (NSCLC), the weekly administration of CBDCA (area under the curve (AUC) 2 mg/ml/min) and paclitaxel (PTX: 40 mg/m) is frequently applied as standard therapy. However, the optimal antiemetic measures in the use of such low-dose CBDCA remain unclear.
View Article and Find Full Text PDFA population pharmacokinetic analysis was performed to investigate the pharmacokinetics of moxifloxacin (400 mg) following a once-daily oral administration in 28 patients with respiratory tract infection disease. The maximum plasma concentration and the area under the plasma concentration-time curve were 3.97 µg/ml and 51.
View Article and Find Full Text PDFBackground: Endobronchial ultrasonography (EBUS) facilitates a lung cancer diagnosis. However, qualitative tissue characterization of lung tumors is difficult using EBUS. Integrated backscatter (IBS) is an ultrasound technique that calculates the power of the ultrasound signal to characterize tissue components in coronary arteries.
View Article and Find Full Text PDF