Publications by authors named "Sayaka Shimodai-Yamada"
Aims: Though the number of patients with peripheral arterial disease (PAD) and critical limb ischemia (CLI) is increasing, few histopathological studies of PAD, particularly that involving below-the-knee arteries, has been reported. We analyzed the pathology of anterior tibial artery (ATA) and posterior tibial artery (PTA) specimens obtained from patients who underwent lower extremity amputation due to CLIMethods: Dissected ATAs and PTAs were subjected to ex-vivo soft X-ray radiography, followed by pathological examination using 860 histological sections. This protocol was approved by the Ethics Review Board of Nihon University Itabashi Hospital (RK-190910-01) and Kyorin University Hospital (R02-179).
View Article and Find Full Text PDFArticle Synopsis
- - The study investigated how recombinant semaphorin 3A (Sema3A) affects heart function and electrical activity in mice with heart failure induced by isoproterenol (ISP).
- - ISP treatment led to increased heart tissue fibrosis and reduced left ventricular contractility, but Sema3A administration improved these issues, showing similar contractility to healthy controls and normalized electric signaling.
- - Molecular analysis revealed that Sema3A upregulates certain proteins (like Kv4.3) associated with heart function, suggesting it helps maintain heart performance by reducing stress on the heart's nervous system and supporting healthy heart tissue.
Aims: Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition with a poor prognosis in which the pulmonary arteries are occluded by organized thrombi. Pulmonary thromboendarterectomy (PEA) is an effective treatment for CTEPH; however, the literature on its histopathological examination is lacking. This study aimed to investigate the histopathological findings and protein and gene expression in PEA specimens, establish an optimal histopathological evaluation method, and clarify the mechanisms of thrombus organization and disease progression in CTEPH.
View Article and Find Full Text PDFArticle Synopsis
- The study found that while SARS-CoV-2 can infect human placental tissue, vertical transmission to the fetus is rare, suggesting the placenta acts as a barrier against the virus.
- Researchers confirmed the presence of the virus's genome in placental tissue using in situ hybridization techniques, showing less presence when using probes that target the virus's spike protein.
- This research provides the first direct evidence that the virus does not replicate efficiently in the infected placenta, highlighting the need for further studies to understand the underlying mechanisms.
Article Synopsis
- The study investigates the tissue responses of coronary arteries after implanting third-generation biodegradable-polymer everolimus-eluting stents (3rd EES) and second-generation durable-polymer stents (2nd EES) using autopsy specimens and a porcine model.
- Results showed a higher coverage ratio of stent struts with 3rd EES compared to 2nd EES (0.824 vs. 0.736), indicating better healing.
- Additionally, the 3rd EES exhibited less fibrin deposition and a quicker formation of healthy tissue (neointima) compared to the 2nd EES after implantation.
Cardiac hemangioma is relatively rare, accounting for approximately 1-3% of all primary heart tumors. This benign tumor may be an incidental lesion, but can also cause arrhythmias, pericardial effusion, congestive heart failure or outflow obstruction. We report a rare case with exophytic cardiac hemangioma arising from the right ventricle.
View Article and Find Full Text PDF