Publications by authors named "Sayaka Matsumoto"

Article Synopsis
  • * Patient symptoms included fever, headache, and hearing loss, with tests revealing infection indicators and abnormal brain lesions confirmed through advanced imaging techniques.
  • * Rapid pathological diagnosis, including immunohistochemistry and PCR, played a vital role in distinguishing the cryptococcoma from a potential malignant tumor, leading to successful antifungal treatment.
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  • Primary intramedullary spinal cord lymphoma (PISCL) is a rare condition that is challenging to diagnose early due to vague symptoms and imaging results, necessitating a biopsy for confirmation.
  • A case study of a 70-year-old woman who exhibited symptoms like lower-limb paralysis and abnormal sensations revealed a spinal mass and high β2-microglobulin levels, pointing toward PISCL.
  • The study emphasizes that in cases resistant to treatment, PISCL should be considered, and spinal cord biopsy should be performed if PET scans show increased FDG uptake and elevated β2-microglobulin in cerebrospinal fluid.
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  • Cardiac tamponade is a rare but serious complication following esophageal cancer surgery that can lead to rapid and dangerous changes in blood pressure and heart function.* -
  • An 86-year-old man developed cardiac tamponade after undergoing a specific type of esophageal surgery, which was treated successfully through surgical drainage procedures.* -
  • The complications arose partly due to anatomical differences in the patient’s heart structure, which may have led to injuries during surgery, resulting in bleeding and a buildup of fluid around the heart.*
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Autosomal dominant episodic ataxia type 2 (EA2) is caused by variants in CACNA1A. We examined a 20-year-old male with EA symptoms from a Japanese family with hereditary EA. Cerebellar atrophy was not evident, but single photon emission computed tomography showed cerebellar hypoperfusion.

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Purpose: This study aimed to investigate the incidence and clinical factors associated with undescended testes (UDT) in patients with congenital diaphragmatic hernia (CDH).

Methods: We retrospectively reviewed the incidence of UDT in male neonates admitted to our institution and underwent surgery for CDH between January 2006 and December 2022. Patients were divided into two groups based on the presence or absence of UDT, and risk factors for UDT were compared between the two groups.

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Purpose: This study aimed to evaluate the feasibility and safety of laparoscopic resection of abdominal neuroblastoma by comparing operative and long-term oncologic outcomes between open and laparoscopic surgeries.

Methods: This single-center retrospective study included patients who underwent laparoscopic tumor resection, between January 2000 and June 2021, with a maximum tumor diameter of ≤ 60 mm and without image-defined risk factors (IDRFs) at surgery. Data from 35 abdominal neuroblastoma resections were reviewed and compared between the laparotomy and laparoscopic groups.

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  • Congenital pulmonary airway malformation is a rare lung condition found in infants, and this report highlights a specific case of a 1-year-old boy with this condition who underwent surgery.
  • The boy was diagnosed prenatally, and preoperative imaging showed a microcystic lesion in his right lung, leading to an elective thoracoscopic segmentectomy when he was 1 year and 4 months old.
  • The surgery successfully removed the affected lung tissue while preserving healthy portions, and the patient had no complications post-surgery, with the histological analysis confirming the diagnosis of stocker type 2 malformation.
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Aims: Sarcopenia is the age-associated atrophy of muscles, and advanced glycation end-products (AGEs) accumulate in patients with age-associated diseases. We aimed to investigate the relationship between AGE accumulation in the skin and sarcopenia in middle-aged and older Japanese people.

Materials And Methods: We enrolled 240 participants in this cross-sectional study.

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Background: Indoor airflow and thermal comfort are difficult to assess through subjective evaluations because airflow sensations can differ based on various factors, such as personal characteristics, interests, preferences, and the current state of mind. Thus, subjective evaluations should be combined with objective assessments, such as physiological measurements. This study evaluated airflow and thermal comfort through physiological measurements, including skin temperature, electroencephalography, respiration, and electrocardiography, in addition to subjective evaluations.

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A woman in her 50s underwent sigmoid colectomy and D3 lymph node dissection for sigmoid cancer(pT3, N0, M0, Stage Ⅱ: Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma 9th). She received adjuvant chemotherapy with capecitabine. Seven months after surgery, contrast-enhanced computed tomography( CECT) scan revealed a small mass in the segment 2 (S2) of the liver with dilation of peripheral intrahepatic bile duct, and the size of this mass and the bile duct dilatation were gradually increased.

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Successful resection of intra-abdominal tumors using indocyanine green (ICG) fluorescence imaging has not been reported. Here, we report a rare case of an intra-abdominal desmoid-type fibromatosis successfully resected using this technique after intersphincteric resection (ISR) for rectal cancer. One year after ISR for rectal cancer in a 47-year-old man, computed tomography showed a 50-mm intra-abdominal tumor near the left common iliac vein.

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Indoor comfort is influenced by airflow direction, but subjective evaluations can differ. This study evaluates the airflow comfort with subjective assessments and physiological measurements, including skin temperature, electroencephalograms, and electrocardiograms. Nineteen participants entered a test room at 20°C after staying in a room at 32°C for acclimation.

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Estrus synchronization requires multiple treatments of hormonal drugs, requiring considerable time and cost. The aim of the present study was to develop an estrus synchronization protocol using intravaginal administration of estradiol benzoate (EB) capsules in goats. Two types of capsules were prepared: an EB capsule that melted immediately after administration and a sustained-release (SR) EB capsule that dissolved slowly and reached a peak after 24 h.

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Formaldehyde (HCHO) is a naturally occurring compound found in ambient air which can induce cancer and sick-building syndrome. It plays an important role in the formation of OH radicals, which are connected to the formation of various airborne chemicals. Herein, we present a simple modeling for the simulation of diurnal variations in the HCHO concentration of ambient air.

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Lisdexamfetamine dimesylate, a prodrug of d-amphetamine, has been approved for treatment of attention-deficit/hyperactivity disorder (ADHD). The purposes of this study were constructing a population pharmacokinetic model of d-amphetamine after dosing of lisdexamfetamine dimesylate and assessing influential factors on the pharmacokinetics of d-amphetamine in Japanese pediatric patients with ADHD. Additionally, the exposure-response relationship was evaluated for Japanese pediatric patients with ADHD using a clinical rating scale, the ADHD Rating Scale IV (ADHD RS-IV, efficacy endpoint) total score as a response index.

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Casein hydrolysate has been shown to improve arterial stiffness as estimated by brachial-ankle pulse wave velocity (baPWV) in untreated hypertensive patients. Facial pigmentation is associated with atherosclerosis, both of which are supposed to be modulated by tissue accumulation of advanced glycation end products (AGEs). However, effects of casein hydrolysate on facial pigmentation and AGEs remain largely unknown.

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The aims of this study were to construct a population pharmacokinetic model of doripenem in neonates and infants and to assess the dosing regimen for patients <3 months of age using Monte-Carlo pharmacokinetic/pharmacodynamic (PKPD) simulations. In the population pharmacokinetic analysis using 187 plasma concentrations from 47 neonates and infants, a two-compartment model well described plasma doripenem concentrations with the most significant covariates of chronological age and gestational age identified for the pharmacokinetics of doripenem. Monte-Carlo simulations suggested that the selected dosages for neonates and infants based on chronological age and gestational age (5 or 10 mg/kg) would provide ≥90% target attainment of 40%fT against MIC of 2 μg/mL in all age groups.

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Article Synopsis
  • Guanfacine hydrochloride extended-release (GXR) is approved for treating ADHD in children and adolescents, and this study aims to develop a pharmacokinetic model for its administration.
  • Researchers analyzed plasma concentration data from 3231 cases of pediatric ADHD patients (ages 6-17) in clinical studies conducted in Japan and the US.
  • Findings indicated that body weight affects guanfacine clearance and distribution; there were no significant pharmacokinetic differences between Japanese and non-Japanese patients, and the treatment showed potential effectiveness in reducing ADHD symptoms even at low doses compared to a placebo.
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The aims of this study were to evaluate the pharmacokinetics of doripenem (Finibax, Doribax, S-4661), a parenteral carbapenem antibiotic, in pediatric patients based on concentrations of doripenem in plasma after administration of 20 mg/kg 2 or 3 times daily and to evaluate the dosing regimens by using Monte-Carlo pharmacokinetic-pharmacodynamic simulations. Population pharmacokinetic analysis was performed by using 190 plasma concentrations of doripenem from 99 patients (2 months-13 years old). The two-compartment model well described the doripenem plasma concentrations in pediatric patients.

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Most intractable tissue-degenerative disorders share a common pathogenic condition, so-called proteinopathy. Amyloid-related disorders are the most common proteinopathies and are characterized by amyloid fibril deposits in the brain or other organs. Aging is generally associated with the development of these amyloid-related disorders, but we still do not fully understand how functional proteins become pathogenic amyloid deposits during the human aging process.

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The liver is a vital organ in the body. It has various essential functions, including detoxification, protein synthesis, and control of infection. Because of its medical importance, liver diseases such as hepatitis and cirrhosis can be crucial for an individual.

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Accurate prediction of human pharmacokinetics (PK) is important for the choice of promising compounds in humans. As the predictability of human PK by an empirical approach is low for drugs with species-specific PK, the utility of a physiologically based pharmacokinetic (PBPK) model was verified using 16 hepatically metabolized reference drugs. After the prediction method for total clearance (CL) and distribution volume at steady state (Vd) in the conventional PBPK model had been optimized, plasma concentrations following a single oral administration of each reference drug to healthy volunteers were simulated, and the prediction accuracy for human PK was compared between empirical approaches and the optimized PBPK model.

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