Publications by authors named "Sayaka Izawa"
Article Synopsis
- Loperamide at lower doses did not affect ECG or MAP parameters, but a higher dose (1 mg/kg) prolonged the QT interval and MAP duration.
- The QT-interval prolongation effect of loperamide was much weaker compared to dofetilide, despite both drugs affecting hERG K channels similar ways, suggesting loperamide has lower access to these channels.
- Naloxone did not influence ECG parameters or the cardiac effects induced by loperamide, indicating that it has a good cardiac safety profile as an antidote.
The removal mechanisms of silicate using an aluminum hydroxide co-precipitation process was investigated and compared with an adsorption process, in order to establish an effective and validated method for silicate removal from wastewater. Adsorption isotherms, XRD and FT-IR analyses showed that silicate uptake occurred by adsorption to boehmite for initial Si/Al molar ratios smaller than two, but by precipitation of poorly crystalline kaolinite for the ratios larger than two, in both co-precipitation and adsorption processes. Silicate was removed by two steps: (i) an initial rapid uptake in a few seconds; and (ii) a slow uptake over several hours in both processes.
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