Insights into the role of phosphorylation on microtubule crosslinking by PRC1.

The mitotic spindle is composed of distinct networks of microtubules, including interpolar bundles that can bridge sister kinetochore fibers and bundles that organize the spindle midzone in anaphase. The crosslinking protein PRC1 can mediate such bundling interactions between antiparallel microtubules. PRC1 is a substrate of mitotic kinases including CDK/cyclin-B, suggesting that it can be phosphorylated in metaphase and dephosphorylated in anaphase.

Evaluation of efficacy of oral ivabradine for attenuation of hemodynamic response to intubation in hypertensive surgical patients: Effect on rate pressure product as an index of myocardial oxygen demand.

Background And Aims: An exaggerated hemodynamic response to endotracheal intubation is observed in hypertensive patients, and its attenuation proves challenging. The role of oral ivabradine, a unique heart rate-lowering drug with a favorable hemodynamic profile, is not yet studied. The aim of this study was to evaluate the effect of oral ivabradine on the attenuation of hemodynamic response to endotracheal intubation in hypertensive surgical patients assessed by rate pressure product (RPP), which is a very reliable indicator of myocardial oxygen demand.

A Novel Association of Colonic Duplication with Mayer-Rokitansky-Kuster-Hauser Syndrome in an Adolescent Girl.

The association is defined as two or more malformations with unclear relationships, which do not fit the criteria of a syndrome. This case report presents a rare finding of tubular colonic duplication in association with Mayer-Rokitansky-Küster-Hauser syndrome in an adolescent girl. The patient presented with gastrointestinal bleeding and abdominal pain, necessitating surgical intervention.

Learners restrict their linguistic generalizations using preemption but not entrenchment: Evidence from artificial-language-learning studies with adults and children.

A central goal of research into language acquisition is explaining how, when learners generalize to new cases, they appropriately restrict their generalizations (e.g., to avoid producing ungrammatical utterances such as "*" indicates an ungrammatical form).

Detection of Esophageal Tuberculosis, a Rare Cause of Abdominal Pain, on F-FDG PET/CT.

The esophagus is rarely affected by A 75-y-old man presented with upper abdominal pain and significant weight loss for 2 mo. Contrast-enhanced CT, upper gastrointestinal endoscopy, and abdominal vessel angiography gave normal results. To clarify the facts, F-FDG PET/CT was performed, revealing an F-FDG-avid lesion in the posterior wall of the lower thoracic esophagus.

Coke oven wastewater treatment using polymeric and ceramic membranes.

This research is aimed to investigate the efficacy of membrane separation technology in treating coke oven wastewater (COW). A comparative study was conducted using three types of membranes: commercial polymeric (CP) membrane, commercial ceramic (CC) membrane, and synthesized ceramic (SC) membrane. The potential of the SC membrane in COW treatment was assessed in comparison to the CC membrane, which had a molecular weight cut-off (MWCO) of 1 Kilo-Dalton.

Radical Resection for Locally Advanced Colon Cancer With Bladder Involvement Treated in a Tertiary Health Care Centre.

Colorectal cancer with involvement of the urinary bladder is infrequent in the nonmetastatic setting. Procedures for advanced colorectal cancers with bladder involvement may include partial or complete bladder resections. Proper therapeutic management principles dictate radical surgery when negative margins can be obtained.

Preventive hepatology at AIIMS Rishikesh: Delivering comprehensive and integrated care for liver diseases in Northern state of India.

Globally, liver diseases accounts for 4% of all deaths. Annually, over 2 million deaths occur due to preventable causes of chronic liver diseases and liver cancer like fatty liver diseases (alcoholic or non alcoholic) and viral hepatitis B and C. The burden of chronic liver diseases are increasing, and the epidemiology and demographics of people affected by these diseases are changing.

Potential Neurologic Manifestations of COVID-19 Infection in Neonates.

In contrast to adults, neonates and infants with coronavirus disease 2019 (COVID-19) infection have milder symptoms and are less likely to require hospitalization. However, some neonates with COVID-19 can present with significant symptoms. Recent evidence suggests that neurologic manifestations of neonatal COVID-19 infection may be higher than initially thought.

Molecular aspects of regeneration in insects.

Regeneration is a fascinating phenomenon observed in various organisms across the animal kingdom. Different orders of class Insecta are reported to possess comprehensive regeneration abilities. Several signalling molecules, such as morphogens, growth factors, and others trigger a cascade of events that promote wound healing, blastema formation, growth, and repatterning.

Physiological alterations and heavy metal accumulation in the transplanted lichen Pyxine cocoes (Sw.) Nyl. in Lucknow city, Uttar Pradesh.

Air pollution has become a major concern due to its detrimental effects on living beings. The present study is aimed at assessing the current status of air pollution in Lucknow city using lichen transplantation technique and assesing its effect on physiology of Pyxine cocoes. The samples of P.

Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes.

The purpose of the present study was to determine the effects of obesity and biological sex on myostatin expression in humans and to examine the direct effects of myostatin, SMAD2, and SMAD3 on insulin signaling in primary human skeletal muscle cells (HSkMCs). For , 15 lean [body mass index (BMI): 22.1 ± 0.

Comprehensive transcriptome analyses of -infected root xylem tissues to decipher genes involved in chickpea wilt resistance.

Unlabelled: Fusarium wilt is the most destructive soil-borne disease that poses a major threat to chickpea production. To comprehensively understand the interaction between chickpea and , the xylem-specific transcriptome analysis of wilt-resistant (WR315) and wilt-susceptible (JG62) genotypes at an early timepoint (4DPI) was investigated. Differential expression analysis showed that 1368 and 348 DEGs responded to pathogen infection in resistant and susceptible genotypes, respectively.

Silicon-based compact eight-channel wavelength and mode division (de)multiplexer for on-chip optical interconnects.

A compact wavelength and mode division (de)multiplexer is proposed for multiplexing a total of eight guided TE modes of a 220 nm thick silicon-on-insulator waveguide with input channels at two wavelengths of 1.55 and 2 µm for wavelength division multiplexing. The (de)multiplexer is composed of four sequentially arranged sections with bus waveguides of increasing widths.

Children learn ergative case marking in Hindi using statistical preemption and clause-level semantics (intentionality): evidence from acceptability judgment and elicited production studies with children and adults.

A question that lies at the very heart of language acquisition research is how children learn semi-regular systems with exceptions (e.g., the English plural rule that yields , etc, with exceptions and ).

Major phenolic compounds, antioxidant, antimicrobial, and cytotoxic activities of (L.) collected from different altitudes in India.

Antibiotic resistance poses a serious threat to public health, raising the number of diseases in the community. Recent research has shown that plant-derived phenolic compounds have strong antimicrobial, antifungal, and cytotoxic properties against a variety of microorganisms and work as great antioxidants in such treatments. The goal of the current work is to evaluate the anticancerous, antibacterial, antifungal, antioxidant, and cytotoxicity activities in the extracts of the different plant parts (leaves, stems, and roots) of (L.

Novel cost-effective design for bio-volatilization studies in photosynthetic microalgae exposed to arsenic with emphasis on growth and glutathione modulation.

A novel laboratory model was designed to study the arsenic (As) biotransformation potential of the microalgae and sp. and the cyanobacterium . The Algae were treated under different concentrations of As(III) to check their growth, toxicity optimization, and volatilization potential.

Comparative Study Between the First and Second Wave of COVID-19 Deaths in India: A Single Center Study.

Introduction  The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously evolving, and many mutant variants of the virus are circulating in the world. Recurrent waves of COVID-19 have caused enormous mortality all across the globe. Considering the novelty of the virus, it becomes crucial for healthcare experts and policymakers to understand the demographic and clinical attributes of inpatient deaths in the first and second waves of COVID-19.

The industrially important genus : An ethnopharmacological review.

, a genus of the family Zingiberaceae, is widely distributed with more than 50 species which are mostly found throughout Southeast Asia. These plants have important ethnobotanical significance as many species are used in Ayurvedic and other traditional medicine preparations. This genus has received a lot of scholarly attention recently as a result of the numerous health advantages it possesses.

Comparative transcriptional analysis of metabolic pathways and mechanisms regulating essential oil biosynthesis in four elite Cymbopogon spp.

Cymbopogon is an important aromatic and medicinal grass with several species of ethnopharmaceutical importance. The genus is extremely rich in secondary metabolites, monoterpenes like geraniol and citral being principal constituents, also used as biomarker for classification and identification of Cymbopogon chemotypes. In the light of this, present study involved RNA sequencing and comparison of expression profiles of four contrasting Cymbopogon species namely C.

Toxicity assessment of metribuzin and its amelioration through plant growth regulators in Vigna radiata (L.) R. Wilczek.

The present experiment was conducted to evaluate the metribuzin-induced stress response in Vigna radiata and to explore the ameliorative role of exogenous application of plant growth regulators (PGRs) against metribuzin toxicity by assessing important biochemical and yield parameters. Prior to the field experiment, dose standardization experiments were performed, and EC was calculated for metribuzin. On day 21, field grown V.

SOI-based compact mode- and polarization-division multiplexer for on-chip optical interconnects: design and simulation.

A compact seven-channel hybrid mode- and polarization-division multiplexer based on a silicon-on-insulator (SOI) waveguide platform is proposed for on-chip optical interconnects. Three independent signals are coupled into the , , and mode of a three moded waveguide using a taper, a polarization beam splitter, and an asymmetric directional coupler in the first coupler section. In the adiabatically connected second and third sections, two collocated asymmetric directional couplers are used to couple two TE modes (, ) and two TM modes (, ) to reduce the footprint of the device.

COVID-19 Infection After Vaccination Among Healthcare Workers at a Tertiary Level Health Care Center in Northern India: A Cross-Sectional Study.

Background And Aims: COVID-19 vaccines are now accessible to all Indian citizens. Infection with COVID-19, on the other hand, continues to spread constantly. Our study aimed to determine the number of persons who had COVID-19 infections despite receiving the recommended number of doses of the COVID-19 vaccination at AIIMS Rishikesh, a tertiary care facility in Uttarakhand, India.

A Glance at the Phytochemical and Ethno-pharmacological Understanding of Four Species.

The genus comprises many species widely cultivated in different parts of the world for their pharmaceutical, neutraceutical and other commercial importance. Many biological activities such as antimicrobial, cytotoxic, anti-nociceptive, anti-inflammatory, hypoglycaemic, hepatoprotective and antioxidant have been ascribed to , which can be linked to the occurrence of biologically active phytochemicals like phenolic acids, essential oil, flavonoids, and terpenes hence making it a potential source for discovery and development of novel drugs. The present review covers the successive advances in the traditional medicinal aspects, phytochemistry, bioactivities and the bioavailability of four species, i.