The International Space Station Environment Triggers Molecular Responses in .

Due to immense phenotypic plasticity and adaptability, is a cosmopolitan fungus that thrives in versatile environments, including the International Space Station (ISS). This is the first report of genomic, proteomic, and metabolomic alterations observed in strain JSC-093350089 grown in a controlled experiment aboard the ISS. Whole-genome sequencing (WGS) revealed that ISS conditions, including microgravity and enhanced irradiation, triggered non-synonymous point mutations in specific regions, chromosomes VIII and XII of the JSC-093350089 genome when compared to the ground-grown control.

Peculiar genomic traits in the stress-adapted cryptoendolithic Antarctic fungus Friedmanniomyces endolithicus.

Friedmanniomyces endolithicus is a highly melanized fungus endemic to the Antarctic, occurring exclusively in endolithic communities of the ice-free areas of the Victoria Land, including the McMurdo Dry Valleys, the coldest and most hyper-arid desert on Earth and accounted as the Martian analog on our planet. F. endolithicus is highly successful in these inhospitable environments, the most widespread and commonly isolated species from these peculiar niches, indicating a high degree of adaptation.

Draft Genome Sequence of the Yeast sp. Strain CCFEE 5036, Isolated from McMurdo Dry Valleys, Antarctica.

A draft genome sequence was assembled and annotated of the basidiomycetous yeast sp. strain CCFEE 5036, isolated from Antarctic soil communities. The genome assembly is 19.

Draft Genome Sequence of an Antarctic Isolate of the Black Yeast Fungus .

A 30.43-Mb draft genome sequence with 10,355 predicted protein-coding genes was produced for the ascomycete fungus strain CCFEE 6314, a black yeast isolated from Antarctic cryptoendolithic communities. The sequence will be of importance for identifying differences among extremophiles and mesophiles and cataloguing the global population diversity of this organism.

International Space Station conditions alter genomics, proteomics, and metabolomics in Aspergillus nidulans.

The first global genomic, proteomic, and secondary metabolomic characterization of the filamentous fungus Aspergillus nidulans following growth onboard the International Space Station (ISS) is reported. The investigation included the A. nidulans wild-type and three mutant strains, two of which were genetically engineered to enhance secondary metabolite production.

Evolution of drug resistance in an antifungal-naive chronic infection.

Management of the limited number of antimicrobials currently available requires the identification of infections that contain drug-resistant isolates and the discovery of factors that promote the evolution of drug resistance. Here, we report a single fungal infection in which we have identified numerous subpopulations that differ in their alleles of a single gene that impacts drug resistance. The diversity at this locus was markedly greater than the reported heterogeneity of alleles conferring antibiotic resistance in bacterial infections.

Phylogenetic and Phylogenomic Definition of Species.

Phylogenomic approaches have the potential to improve confidence about the inter-relationships of species in the order Mucorales within the fungal tree of life. species are especially important as plant and animal pathogens and bioindustrial fermenters for food and metabolite production. A dataset of 192 orthologous genes was used to construct a phylogenetic tree of 21 strains, classified into four species isolated from habitats of industrial, medical and environmental importance.

Draft Genome Sequences of the Antarctic Endolithic Fungi CCFEE 5527 and sp. CCFEE 5018.

The draft genome sequences of CCFEE 5527 and sp. CCFEE 5018 are the first sequenced genomes from this genus, which comprises rock-inhabiting fungi. These endolithic strains were isolated from inside rocks collected from the Antarctic Peninsula and Battleship Promontory (McMurdo Dry Valleys), Antarctica, respectively.