Publications by authors named "Sawsan G A A Mohammed"
Article Synopsis
- Next-generation sequencing (NGS) is helping to identify rare germline genetic variations linked to inherited diseases, such as cancer predisposition syndromes (CPSs), which are significant factors in childhood cancers.
- There is no consensus on guidelines for germline genetic testing in children with cancer due to the advancing knowledge in NGS technology, prompting recommendations for clinical screening to identify high-risk individuals.
- The text discusses the clinical features of CPSs, ethical considerations, challenges in implementation, and proposes a systematic approach for integrating genomic newborn screening into healthcare to improve pediatric cancer care.
Biomedicines
January 2024
Article Synopsis
- Immunotherapy harnesses and modulates the immune system to combat various cancers by targeting specific immune components and checkpoint inhibitors, utilizing monoclonal and polyclonal antibodies along with therapies like CAR T cell and dendritic cell treatments.
- The advancement of techniques, such as CRISPR-Cas9, has improved the effectiveness of CAR T cell therapies, enhancing their ability to fight tumors.
- Despite these innovations, challenges remain, including the potential for resistance to immunotherapy and the additional complications introduced by COVID-19, which can affect immune responses and treatment outcomes.
