Evaluating the respective weights of some facial signs on the perceived radiance/glow in differently aged women of six countries.

Objectives: To evaluate the impact of Facial radiance or Glow on the perception of age (PA) and to assess which facial signs most influence PA.

Material And Methods: The faces of 1058 differently aged women (18-80 years) of six different ethnicities/countries (China, Japan, Korea, India, South Africa, and Brazil) were photographed under standard conditions. These allowed to focus on 20 different facial signs that were further graded by experts, using referential Atlases dedicated to facial aging.

A predictor of aerobic threshold for patients with heart failure with reduced ejection fraction.

[Purpose] The initial cardiopulmonary response to exercise is hypothesized to be a useful predictor of aerobic threshold in patients with heart failure. This study aimed to evaluate the correlation between aerobic threshold and cardiopulmonary responses to exercise onset by comparing patients with heart failure using preserved (≥50%) and reduced (<50%) left ventricular ejection fractions. [Participants and Methods] Twenty-eight males (age, 36-82 years; 12 with preserved and 16 with reduced left ventricular ejection fractions) underwent a progressive submaximal cardiopulmonary exercise test using a cycle ergometer.

AAV-mediated IL-10 gene transfer counteracts inflammation in the hypothalamic arcuate nucleus and obesity induced by high-fat diet.

Consumption of high-fat diet (HFD) induces energy imbalance and consequently obesity. In the pathogenesis of obesity, HFD triggers inflammation in the hypothalamus including arcuate nucleus (ARC). Interleukin-10 (IL-10) is a representative anti-inflammatory cytokine, known to ameliorate the adipose tissue inflammation and insulin resistance in obesity.

Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+) influx through L-type channels in mouse islet β-cells.

Nucleobindin-2 (NUCB2)-derived nesfatin-1 located in the brain has been implicated in the satiety and control of energy metabolism. Nesfatin-1 is also produced in the periphery and present in the plasma. It has recently been reported that NUCB2/nesfatin-1 is localized in pancreatic islet β-cells in mice and rats and released from islets.