Publications by authors named "Sawai Singh Rathore"
Objective: Giant cell arteritis (GCA) is a chronic inflammatory condition associated with a significantly increased risk of various cardiovascular and thromboembolic events. Existing studies suggest an increased risk of cardiovascular disease in GCA, but results vary. This meta-analysis aims to quantify the association between GCA and the risk of various cardiovascular outcomes, providing a comprehensive evaluation of the cardiovascular burden in patients with GCA.
View Article and Find Full Text PDFIntroduction: PCSK9 inhibitors are a novel class of medications that lower LDL cholesterol (LDL-C) by increasing LDL receptor activity, promoting clearance of LDL-C from the bloodstream. Over the years, PCSK9 inhibitors have been explored as adjunct therapies to statins or as monotherapy in high-risk cardiovascular patients.
Aim: This review aims to provide an updated perspective on PCSK9 inhibitors, assessing their clinical efficacy, safety, and significance, especially in light of recent clinical trials.
Background: Coagulopathy and thromboembolic events are associated with poor outcomes in coronavirus disease 2019 (COVID-19) patients. There is conflicting evidence on the effects of chronic anticoagulation on mortality and severity of COVID-19 disease.
Aim: To summarize the body of evidence on the effects of pre-hospital anticoagulation on outcomes in COVID-19 patients.
This meta-analysis aimed to assess the outcomes of patients with atrial fibrillation undergoing chronic hemodialysis, comparing the effectiveness of direct oral anticoagulants (DOACs) and vitamin K antagonists. A systematic search was conducted across various databases including PubMed, Embase, and Google Scholar. Efficacy outcomes focused on the risk of stroke and mortality, whereas safety outcomes assessed the risk of bleeding.
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- * A meta-analysis of 21 articles involving 26,933 COVID-19 patients found a UGIB prevalence of 2.10%, with significant rates of severity (55%), mortality (29%), and rebleeding (12.7%).
- * UGIB in COVID-19 patients is associated with worse outcomes, showing increased odds of severe illness (3.52 times) and higher mortality (2.16 times) compared to those without UGIB, emphasizing the need for prompt clinical attention.
New-onset atrial fibrillation (NOAF) in COVID-19 raises significant clinical and public health issues. This systematic review and meta-analysis aims to compile and analyze the current literature on NOAF in COVID-19 and give a more comprehensive understanding of the prevalence and outcomes of NOAF in COVID-19. A comprehensive literature search was carried out using several databases.
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- * The overall prevalence of myocarditis in dengue fever is 12.4%, with a higher rate in Asia (15.2%) compared to Latin America (3.6%).
- * Patients with myocarditis face a significantly increased risk of severe disease (RR=2.44) and mortality (RR=19.41), emphasizing the importance of early identification and management in dengue cases.
Article Synopsis
- A systematic review and meta-analysis was conducted to explore the relationship between pre-existing celiac disease (CD) and outcomes of COVID-19, as there is limited scientific evidence on this topic.
- The analysis included data from 11 studies with a total of 44,378 CD patients, revealing a SARS-CoV-2 infection rate of 4.25% among them.
- Findings suggested that having CD does not significantly increase the risk of hospitalization or mortality due to COVID-19 compared to individuals without CD, but more research is needed for conclusive results.
Background: Left ventricular assist device (LVAD) implantation is frequently employed in patients with end-stage heart failure. The outcomes of addressing the repair of all substantial aortic valvular disease at the time of LVAD implantation remain unclear. We sought to assess the clinical outcomes in patients undergoing LVAD implantation concomitant with aortic valve procedures (AVPs) compared with isolated LVAD implantation.
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- The study analyzed the incidence, predictors, and outcomes of early hospital readmissions (EHR) within 30 days after kidney transplantation.
- A total of 17 studies found that the pooled incidence of EHR was 24.4%, correlating with factors like older recipient and donor age, Black race, diabetes, and delayed graft function.
- EHR was linked to higher risks of graft failure and mortality within the first year post-transplant, highlighting the need for improved management strategies to reduce EHR rates.
With COVID-19 still hovering around and threatening the lives of many at-risk patients, an effective, quick, and inexpensive prognostic method is required. Few studies have shown fibrinogen to albumin ratio (FAR) and C-reactive protein to albumin ratio (CAR) to be promising as prognostic markers for COVID-19 disease. However, their implications remain unclear.
View Article and Find Full Text PDFMitral valve repair (MVr) secondary to degenerative anterior/bi-leaflet mitral valve disease is more challenging than posterior leaflet repair. However, conclusive evidence is needed to make decisions based on the outcomes rather than technical difficulties. This meta-analysis compares anterior/bi-leaflet MVr with isolated posterior leaflet repair in patients with mitral regurgitation (MR) due to degenerative mitral valve disease.
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- - Obesity significantly increases the risk of severe COVID-19 outcomes, with a 52% higher risk for admission to ICUs and a notable association with higher mortality rates.
- - The study analyzed data from over 3.1 million patients across 167 studies, highlighting that factors like age, gender, and existing health conditions also influence the severity and mortality rates in obese COVID-19 patients.
- - The research underscores the importance of considering obesity and related health issues in managing COVID-19, as they contribute to worse outcomes for affected individuals.
Article Synopsis
- The study investigates the impact of dengue virus (DENV) infection on pregnant women and their babies, highlighting the potential risks involved.
- It analyzes data from 36 studies involving nearly 40,000 DENV-infected pregnant women, finding increased risks of maternal mortality, stillbirth, and neonatal deaths associated with the infection.
- The conclusion emphasizes that pregnant women are a vulnerable group for dengue and should be prioritized in management programs to mitigate these risks.
Hypertriglyceridemia is known to be the third most common etiology of acute pancreatitis. Triglyceride levels above 1,000 mg/dL are associated with an increased risk of acute pancreatitis. We present the case of a 22-year-old female, a known case of hypertriglyceridemia, who developed sudden onset severe epigastric abdominal pain.
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- The study compared the effectiveness of ProGlide® and MANTA® vascular closure devices (VCDs) for managing large-bore access sites, as previous studies were underpowered.
- A systematic search was conducted across several databases for relevant articles, focusing on various bleeding and vascular complication outcomes.
- Results showed no significant differences in bleeding and complications between the two devices, but ProGlide® had a higher rate of device failure compared to MANTA®.
Background: Takotsubo cardiomyopathy (TC) or stress-induced cardiomyopathy is a transient heart condition that clinically resembles an acute coronary syndrome. This study aims to assess the incidence of life-threatening arrhythmias in patients with Takotsubo cardiomyopathy and evaluate the outcomes of patients with life-threatening arrhythmias (LTAs) in Takotsubo cardiomyopathy compared with those without LTA.
Methods: We comprehensively searched the PubMed, Google Scholar, and Embase databases from inception to February 2021.
Article Synopsis
- - The review aimed to evaluate whether the use of ACE inhibitors (ACEIs) and Angiotensin-II receptor blockers (ARBs) affected mortality and disease severity in COVID-19 patients.
- - A comprehensive search led to the inclusion of 53 studies for mortality analysis and 43 for severity, revealing no significant impact on either outcome when patients were on ACEIs/ARBs.
- - Additionally, meta-regression showed that demographic factors, such as age and existing heart disease, explained some variations in study results, but the medications did not correlate with mortality or severity.
Objectives: Motoric cognitive risk syndrome (MCR) is a recently proposed predementia syndrome characterized by subjective cognitive impairment and slow gait. We aim to assess the cardiovascular and noncardiovascular factors associated with MCR.
Design: Systematic review and meta-analysis.
This systematic review focuses on the clinical features, physical examination findings, outcomes, and underlying pathology of acute telogen effluvium (TE), a type of diffuse hair loss, occurring in coronavirus disease 2019 (COVID-19) recovered patients. MEDLINE/PubMed and Embase databases were queried till October 2021 to identify studies reporting acute TE occurring after COVID-19 recovery. Data were obtained from 19 studies, which included 465 patients who were diagnosed with acute TE.
View Article and Find Full Text PDFAlthough rare, drug-induced pancreatitis is an important cause of acute pancreatitis. The diagnosis of drug-induced pancreatitis remains a challenge for clinicians. Steroids are one of the frequently used drugs in hospitals for many acute illnesses.
View Article and Find Full Text PDFObjective: The current study has been conducted to identify the risk factors associated with blood transfusion in women undergoing cesarean section (C-section). A detailed account of the risk factors associated withblood transfusion will ultimately prevent unnecessary crossmatching in hospitals , leading to the conservation of declining blood supplies and resources without subjugating the quality of care.
Material And Methods: We performed a rigorous literature search using electronic databases, including PubMed, Cochrane CENTRAL, and Embase, for studies evaluating the risk factors for blood transfusion in C-section published until March 31, 2021.
Background: Crimean-Congo haemorrhagic fever (CCHF) is a fatal acute tick-borne viral infection and substantial emerging global public health threat. This illness has a high case fatality rate of up to 40%. The liver is one of the important target organs of the CCHF virus.
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