Efficacy of Concentrated Growth Factors in Treating Tympanic Membrane Perforation in Guinea Pigs.

Background: Less invasive and cost-effective alternatives are needed to manage tympanic membrane perforation (TMP). Therefore, the effectiveness of concentrated growth factors (CGF) in promoting tympanic membrane regeneration in guinea pig models of eardrum perforation was invetigeted. Methods: Large TMPs were created in 34 guinea pig ears using a CO2 laser and divided into 3 groups: CGF-gelatin sponge (with-CGF group), saline-gelatin sponge (without-CGF group), and untreated group.

Effect of hormonal therapy on the otoconial changes caused by estrogen deficiency.

Benign paroxysmal positional vertigo (BPPV) is associated with menopause and/or osteopenia. Morphological changes in the otoconial layer have been reported after ovariectomy (OVX). Moreover, hormone replacement therapy decreases BPPV risk.