Publications by authors named "Savitha Bhaskaran"
Background: Cancer is a deadly disease, which is due to the uncontrolled division of cells with abnormal or unusual characteristics. It is a consequence of lethal mutations occurring due to various chemical and physical carcinogens, affecting many cellular signalling pathways and leading to uncontrolled proliferation. In this study, we analyzed the effect of 4-(1H-imidazol-1-yl)-N-(2-(3-(4-methylbenzyl) ureido) ethyl)benzamide (IMUEB), an imidazole derivative, on A549 cells (lung cancer cells).
View Article and Find Full Text PDFCancer is the second most dreaded disease worldwide. It is either acquired or inherited leading to the accompanying undesirable changes in the affected cells. Most existing chemotherapeutic drugs show enormous side effects.
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- A new catalytic method was developed for synthesizing 7-(hetero) aryl-1H-pyrrolo[2,3-c]pyridine compounds using microwave-assisted Suzuki-Miyaura cross-coupling, achieving excellent yields.
- The method effectively utilizes various boronic acids and potassium organotrifluoroborates, highlighting the importance of stable monoligated catalytic species for successful reactions.
- A highly efficient precatalytic system (XPhos-PdG2) was employed, which facilitates rapid reaction rates with low catalyst amounts, demonstrating the method's versatility with 7-chloro, 6-azaindole systems featuring free N-H groups.