Psiguanol, a novel α-pyrone derivative from Psidium guajava leaves and vasorelaxant activity in rat aorta cells through intracellular cGMP-dependent opening of calcium-activated potassium channels.

The phytochemical investigation of leaves led to the isolation of total nineteen compounds which belongs to meroterpenoids, flavonoid, phenolics, and triterpenoids. The compounds were isolated using extensive chromatography techniques and identified as psiguanol (), as new compound along with guajadial (), psidial A (), -caryophyllene (), quercetin (), avicularin (), guaijaverin (), hyperin (), rutin (), ursolic acid (), corosolic acid (), asiatic acid (), -sitosterol (), -sitosterol-D-glucoside (), ellagic acid (), 3,3',4'-trimethylellagic acid 4-O-glucoside (), protocatechuic acid (), gallic acid (), and tricosanoic acid () as known molecules. The compound was isolated for the first time from this plant.

Vasorelaxant property of 2-phenyl ethyl alcohol isolated from the spent floral distillate of damask rose (Rosa damascena Mill.) and its possible mechanism.

Ethnobotanical Relevance: Rosa damascena Mill. (Rosaceae), commonly known as damask rose, is an ancient medicinal and perfumery plant used in Traditional Unani Medicine due to various therapeutic effects, including cardiovascular benefits.

Aim Of The Study: This study aimed to evaluate the vasorelaxant effect of the 2-phenyl ethyl alcohol (PEA) isolated from the spent flowers of R.

Dual targeted 2-Benzylideneindanone pendant hydroxamic acid group exhibits selective HDAC6 inhibition along with tubulin stabilization effect.

Abnormal epigenetics has been recognised as an early event in tumour progression and aberrant acetylation of lysine in particular has been understood in tumorigenesis. Therefore, it has become an attractive target for anticancer drug development. However, HDAC inhibitors have limited success due to toxicity and drug resistance concerns.

The development of sustainable IoT E-waste management guideline for households.

The introduction of new technology, such as the Internet of Things (IoT), entails a growth in digital devices, which could ultimately result in a high amount of electronic trash (e-waste) production if they are not appropriately managed. Apart from that, the regulation on possible "IoT E-waste" generation is yet to be regulated, probably due to the new development and implementation of IoT globally. Hence, this paper proposed a Sustainable IoT E-waste Management guideline for households.

Vimentin positive acantholytic penile squamous cell carcinoma with rhabdoid features.

Acantholytic variant of penile squamous cell carcinoma (SCC) is an exceedingly rare and associated with bad prognosis. Histologically it mimics angiosarcoma due to pseudovascular spaces. Vimentin immunopositivity in such cases represent epithelial to mesenchymal transition manifested by cellular discohesion.

Laparoscopic CBD Exploration.

Laparoscopic CBD exploration (LCBDE) is a cost effective, efficient and minimally invasive method of treating choledocholithiasis. Laparoscopic Surgery for common bile duct stones (CBDS) was first described in 1991, Petelin (Surg Endosc 17:1705-1715, 2003). The surgical technique has evolved since then and several studies have concluded that Laparoscopic common bile duct exploration(LCBDE) procedures are superior to sequential endolaparoscopic treatment in terms of both clinical and economical outcomes, Cuschieri et al.

Combined procedures with laparoscopic cholecystectomy.

With advancement in laparoscopic surgery a number of surgical procedures can be performed combined with laparoscopic cholecystectomy in a single surgery. We evaluate the safety & efficacy of such surgeries. A retrospective review of all patients who had undergone combined procedures with laparoscopic cholecystectomy during January 2005 to June 2009 was performed.

Laparoscopic repair of a right para duodenal hernia.

Para duodenal hernia is among the uncommon and rare causes of intestinal obstruction, but it is the most common type of internal hernia in abdomen and accounts for more than half of cases that do occur. Here, we are reporting a case of right Para duodenal hernia, reduced and repaired laparoscopically. This thirteen year old girl presented to us with features of small bowel obstruction of two days duration.