Antihyperglycemic activity of a novel polyherbal formula (HF344), a mixture of fifteen herb extracts, for the management of type 2 diabetes: Evidence from and studies.

Antihyperglycemic effects of a novel polyherbal formula (HF344), comprising fifteen Thai herbal extracts, were elucidated for pharmacological mechanisms and potential for managing type 2 diabetes mellitus, by employing , , and approaches. LC/MS analysis of HF344 extract revealed several phytoconstituents, with piperine identified as the major active compound. HF344 extract significantly enhanced insulin secretion in RINm5F cells and inhibited glucose uptake into the everted sacs of the mouse small intestine in a concentration-dependent manner compared to the control (p < 0.

Anti-oral streptococci and anti-biofilm properties of essential oil and its bioactive compounds proposed for an alternative herbal mouthwash.

Oral streptococci are the major group of bacteria in the oral cavity. Some of their species cause oral diseases that may lead to tooth loss and quality-of-life reduction, such as dental caries. One of prevention techniques to promote oral health is rinsing mouthwash after toothbrushing.

Synergistic effect of Trikatuk, a traditional Thai formulation, on antioxidant and alpha-glucosidase inhibitory activities.

Oxidative stress and hyperglycemia are known to be responsible for several diseases, including diabetes. To prevent these diseases, efforts are ongoing to identify novel antioxidants with hypoglycemic effects. Trikatuk is a traditional Thai formulation composed of three herbs in equal quantities: the fruits of and and the rhizomes of .

Antihyperglycemic effects of leaf extract and .

Context: (Craib) A. Schmitz (LS) (Fabaceae) has traditionally been used to treat diabetes mellitus.

Objective: This study demonstrates the antidiabetic and antioxidant effects of aqueous extract of LS leaves and .

Inhibitory effects of Triphala on CYP isoforms and its pharmacokinetic interactions with phenacetin and midazolam in rats.

Context: Direct evidence of Triphala-drug interactions has not been provided to date.

Objective: This study was aimed to determine the effects of Triphala on cytochrome P450 (CYP) isoforms and P-glycoprotein (P-gp) and to investigate pharmacokinetic interactions of Triphala with CYP-probes in rats.

Materials And Methods: Effects of Triphala on the activities of CYP isoforms and P-gp were examined using human liver microsomes (HLMs) and Caco-2 cells, respectively.

Yanangdaengin, a dihydrochalcone glucoside galloyl ester as active antioxidative agent from leaves of (syn. ).

Objective: To isolate and identify the major bioactive components from the leaves of , an indigenous herb used in traditional Thai medicine for detoxification, longevity, and some other health related issues.

Methods: Comparative HPLC analyses of the crude extracts from three provenances were carried out for an overview of characteristic compound profiles. Isolation of the major compounds was undertaken with chromatographic methods.

A validated HPTLC method for quantitative analysis of morin in heartwood.

Objective: The study was conducted to develop and validate a high performance thin-layer chromatography (HPTLC)-densitometric method for the quantitative analysis of morin in heartwood collected from different locations in Thailand.

Methods: HPTLC analysis was performed on an aluminium sheet of silica gel 60 F254 using toluene: ethyl acetate: formic acid (36:12:7, volume percent) as a mobile phase. The densitometric scanning was performed at the wavelength 410 nm.

and evidence of hypouricemic and anti-inflammatory activities of (Lour.) Corner heartwood extract.

(Lour.) Corner (MC) heartwood extracts have been used for the treatment of gout, hyperuricemia, and inflammation in Thai traditional medicine. Despite their traditional use, their mechanisms of action remain unknown.

Antidiabetic effects of (Lour.) corner heartwood extract.

Background And Aim: (MC) (Lour.) heartwood extract have been used traditionally to treat diabetes in Thailand, but their mechanism of action has not been elucidated.

Experimental Procedure: This study investigated the effects of an aqueous heartwood extract of MC on α-glucosidase and α-amylase activities.

Simultaneous HPTLC Determination of Rhein and Aloe-emodin in Senna alata Leaves from Thailand and their Commercial Products.

A high performance thin layer chromatographic (HPTLC) method was developed and validated for simultaneous determination of rhein and aloe-emodin, major anthraquinone constituents, in S. alata leaves. The separation was performed on a silica gel 60 F₂₅₄ HPTLC plate using ethyl acetate: methanol: water (100:17:10, v/v/v) as the development system.

HPLC quantitative analysis of rhein and antidermatophytic activity of Cassia fistula pod pulp extracts of various storage conditions.

Cassia fistula is well known for its laxative and antifungal properties due to anthraquinone compounds in the pods. This study quantitatively analyzed rhein in the C. fistula pod pulp decoction extracts kept under various storage conditions using HPLC.