Publications by authors named "Savioz M"
Article Synopsis
- The study used a pig model to analyze how various factors, like donor weight and temperature differences, affect the cooling speed of kidneys during organ procurement.
- The cooling process follows an exponential decay model, with a faster cooling rate linked to higher cellular viability ratios (CVR).
- Results showed that when cooling exceeds 1°C/min, the mean CVR is significantly better (91%) than when it drops below that threshold (75%), suggesting current cooling rates may be inadequate.
Objective: To assess the relationship between postoperative infective complications and the CD4 count.
Design: Retrospective and biometric study.
Setting: Two university hospitals, Switzerland.
We have determined the kinetics of the cellular viability ratio (CVR), defined as the number of living cells over the total cell count, in pig kidneys using propidium iodide and fluorescein diacetate staining, as a function of time and preservation conditions. The kidneys were preserved in warm or cold ischemia in order to mimic the conditions of transplantation from non-heart-beating donors or multiple removal with optimal preservation of the graft, respectively. To determine the CVR, the cells were obtained by a fine-needle aspiration biopsy, which minimizes the damage to the graft.
View Article and Find Full Text PDF