Visualization for better understanding global sensitivity analysis results: The case of safety assessment of radioactive waste disposal.

Sensitivity analysis answers questions about the influence of parameters on the simulation results and plays a significant role in the development of environmental models by helping to understand the relations within the model and test its adequacy. Comparison of various sensitivity analysis approaches is often also quite useful because different methods employ different measures for ranking model parameters and their unconformities and disagreements provide additional information on model behavior. The visual representation of numerical results is crucial for their correct interpretation, and at first sight, the visualizations for the sensitivity analysis should be quite universal because in most cases an outcome of sensitivity analysis is the same: a set of indices measuring the significance of model inputs for the selected output.

Phyto-nano-hybrids of Ag-CuO particles for antibacterial activity against drug-resistant pathogens.

Background: The present study reports the antibacterial potential of phyto-nano-hybrid particles Ag-CuO (silver-copper oxide) against drug-resistant pathogens isolated from a Russian hospital in Krasnoyarsk, Siberia. The synthesis of nano-hybrid was achieved by phytogenic source by using leaves of Murraya koenigii. The nano-hybrid particles were well characterized using hyphenated techniques and results of the antibacterial assay was tabulated.

[The inhibitors of the apical sodium-dependent bile acid transporter (ASBT) as promising drugs].

Inhibition of the apical sodium-dependent bile acid transporter (ASBT, also known as IBAT - ileal bile acid transporter, SLC10A2) leads to disruption of the enterohepatic circulation of bile acids and their excretion with fecal masses. This is accompanied by cholesterol utilization for synthesis of new bile acids. ASBT inhibitors are promising drugs for the treatment of such diseases as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, type 2 diabetes mellitus, necrotic enterocolitis, chronic constipation, atherosclerosis.

[Vascular mechanisms in Meniere's disease].

Meniere's disease (MD) is chronic multifactorial medical condition caused by endolymphatic hydrops, which etiology is unclear. This review highlights possible vascular mechanisms of MD. Impairment of vascular regulation, further ischemic damage of labyrinth and venous drainage pathology could lead to endolymphatic hydrops.

[Improvement of laboratory diagnostics of cholera due to genetically altered (hybrid) variants of cholera Vibrio biovar El Tor].

Aim: Improvement of laboratory diagnostics of cholera taking into the account appearance of hybrid variants of cholera vibrio El Tor biovar in the 1990s.

Materials And Methods: Phenotypic and molecular-genetic properties of typical toxigenic (151 strains) and hybrid (102 strains) variants of El Tor biovar cholera vibrios, isolated in the Caucuses in 1970-1990 and 1993-1998, respectively, were studied. Toxigenicity gene DNA fragments, inherent to El Tor biovars or classic, were detected by using a reagent kit "Genes of Vibrio cholerae variant ctxB-rstR-rstC, REF" developed by us.

[Analysis of sequences of ITS1 internal transcribed spacer and 5.8S ribosome gene of Malus species].

The nucleotide sequence of the ITS1-5.8S ribosomal DNA spacer fragment was determined for 41 samples of the Malus species. The total length of compared sequences ranged from 389 to 392 bp.

[Clinical peculiarities of diagnostics of sensorineural loss of hearing and deafness in children].

The clinical features of various subjective and objective methods for the study of the hearing function were evaluated based on the results of examination of 46 children presenting with sensorineural hearing loss and deafness. The factors that influence the effectiveness and quality of diagnostics of sensorineural loss of hearing in the children were elucidated.

[The hearing function in the patients presenting with the intralabyrinthine distribution of giant cholesteatoma].

The objective of the present study was to evaluate the state of the hearing function in the patients presenting with the intralabyrinthine distribution of giant cholesteatoma before and after the surgical treatment based on the results of examination by the subjective and objective methods. The possibility of preservation of the hearing function after the surgical intervention has been demonstrated.

Autoantibodies to neuron-specific proteins S100, GFAP, MBP and NGF in the serum of rats with streptozotocin-induced diabetes.

The appearance of autoantibodies to neuronal proteins (S100, GFAP, MBP, and NGF) in rat serum was analyzed by ELISA on days 5, 10, 17, 25, and 32 after streptozotocin injection. Simultaneously, blood glucose and insulin autoantibodies were assayed. Serum glucose level increased on the next day after streptozotocin injection and the level of autoantibodies to insulin significantly increased on day 5 indicating the development of diabetes.

[Resonant characteristics of the external acoustic meatus in the children undergoing electroacoustical correction of hearing].

The objective of this study was to estimate the factors influencing the efficacy and quality of electroacoustical correction of hearing in the children and elucidate specific resonant characteristics of the external acoustic meatus in the patients at the age varying from 6 months to 5 years. The hearing acuity was estimated in 87 children aged from 5 months to 5 years presenting with censorineural impairment of hearing or deafness with the use of psychoacoustic and electrophysiological techniques. Special attention was given to the assessment of resonant characteristics of the external acoustic canal.

[Currently possibilities for diagnostics and electroacoustical correction of hearing in the children].

This study was designed to compare different objective methods applied to study the hearing function in 132 children presenting with sensorineural impairment of hearing and deafness. It was focused on the assessment of risk factors of congenital and acquired loss of hearing and deafness. In addition, the factors influencing the efficacy and quality of electroacoustical correction of hearing in the children were considered including those of importance after cochlear implantation.

[Comparative study of the biological properties of various nutrient media used for the isolation of Legionella pneumophila].

Three diagnostic selective media used for the isolation of Legionella pneumophila were compared. These included BCYEAalpha (Oxoid, a reference medium), BCYEAalpha (Hi Media), and elective legionellosis medium (ELM) developed at the Rostov-on-Don Research Institute for Plague Control. The virulent L.

[Neuroendocrine complexes in the pancreas of nutria (Myocastor coypus) (an immunohistochemical study)].

With the application of a double immunohistochemical labeling method, several types of neuroendocrine interactions were demonstrated in the pancreas of nutria. Two types of neuroinsular complexes were detected that have the organization typical to the mammals. It was found to be typical of nutria that several pancreatic islets were integrated with nerve cells and nerve fibers.

Immunohistochemical detection of SNAP-25, NCAM, and insulin in the pancreas of nutria (Myocastor coypus).

Immunohistochemical study revealed three types of neuroendocrine contacts in nutria pancreas. In most cases, the pancreatic islets and individual endocrine cells were associated with a diffuse neural network. Integration of neural ganglia with the islets and innervation of endocrine cells by projections of ganglionic cells were detected.

Meta-analyses with binary outcomes: how many studies need to be omitted to detect a publication bias?

Meta- and pooled analyses are increasingly applied to aggregate the results of a number of studies, especially in health sciences. A typical difficulty is the presence of a publication bias. Usually Egger's regression test and funnel plots are applied to detect such a publication bias.

[Genetic aspects of individual sensitivity to betaxolol in patients with arterial hypertension].

Association of polymorphism of b1-adrenoreceptors gene and cytochrome 2D6 gene with efficacy of b-adrenoblocker betaxolol was studied in 81 patients with I and II degree arterial hypertension. Betaxolol (10-20 mg/day) was given for 4 weeks, its efficacy was assessed by office blood pressure (BP) measurements, 24-hour BP and ECG monitoring and standard exercise test. At the end of the study significant lowering of systolic and diastolic BP was noted by 11,8 +/- 2,47 (p=0,001) and 7,8 +/- 1,68 mm Hg (p=0,001), respectively.

Association of CYP2D6 and ADRB1 genes with hypotensive and antichronotropic action of betaxolol in patients with arterial hypertension.

Betaxolol is a selective antagonist of beta(1)-adrenergic receptors. Personal response to the drug widely varies and depends on its properties and individual features including innate characteristics. Our aim was to study the association between the clinical response to betaxolol in patients with essential hypertension (EH) and polymorphous markers of two genes: beta(1) adrenergic receptor gene (ADRB1) and cytochrome P450 2D6 gene (CYP2D6).

[Improvement of efficacy of electroacoustic hearing correction in patients after radical surgery on the middle ear].

Sound pressure was measured in the ears of 95 patients who had a cavity after radical operation of the middle ear. Changes of normal architectonics of the middle ear entail changes in resonance characteristics of the ear which must be considered in electroacoustic hearing correction. Effects of various modifications of ear insert on frequency characteristics were estimated.

[Mechanism of action of biogenic chloramines and hypochlorite on initial aggregation of blood platelets].

The antiaggregant action of two reactive oxidants N,N-dichlorotaurine (chloramine of biogenic type) and sodium hypochlorite on the initial ADP-induced aggregation of rabbit blood platelets has been studied. Platelet aggregation in the reconstructed platelet-rich plasma (PRP) was measured by the nephelometric method, and the aggregation index was an increase in the intensity of small-angle light scattering. The introduction of chloramine at comparatively small concentrations (no greater than 1 mM active chlorine) directly into the reconstructed platelet-rich plasma induces the suppression of the initial aggregation (formation of small aggregates) several times stronger than in the case of its preliminary incubation with plasma alone.

[Prospects in getting accordance between chemical analytic control means and medical technical requirements to safety system concerning chemical weapons destruction].

The major unit monitoring chemical weapons destruction objects is a system of chemical analyticcontrol over the technologic process procedures and possibility of environment and workplace pollution withtoxicchemicals and their destruction products. At the same time, physical and chemical control means meet sanitary and hygienic requirements incompletely. To provide efficient control, internationally recognized approaches should be adapted to features of Russian system monitoring pollution of chemical weapons destruction objects with toxic chemicals.

[Hypophyseal hormones in young patients with breast cancer].

Hypophyseal hormones were studied in comparison with cellular and humoral immunity in young and middle aged females with breast cancer and controls matched by age. No correlation existed between LH concentrations and cellular, humoral immunological parameters in young breast cancer patients. Basal secretion of FSH directly correlated with the activation markers expression (antigens CD30, CD38) only in young patients.

[New aspects of adoptive immunochemotherapy in disseminated forms of cancer].

A method of autolymphochemotherapy was developed based on administration of a "therapeutic" course of chemotherapy following cytotoxic treatment of a large amount (1.5-2 l) of central lymph obtained by external drainage of the thoracic duct. Immediate results of treatment of 15 patients with advanced breast, lung (non-small-cell) and ovarian cancer with various degree of chemoresistance are presented.

[The lymphocyte immunological phenotype of young and middle-aged breast cancer patients].

The immunologic phenotype of lymphocytes of young and middle-aged patients with breast cancer was identified using ICO monoclonal antibodies. The parameters were compared to that of healthy subjects of the corresponding age groups. Breast cancer patients of both age groups were shown to have lower T-cell level as compared to donors.

[Estradiol-17beta, sex steroid-binding globulin and the cellular and humoral immunity indices in young women with breast cancer].

Blood serum levels of sex steroid-binding globulin (SSBG), free and SSBG- and albumin-binding fractions of estradiol-17 beta as well as some indexes of cellular and humoral immunity were compared in 25 young female patients with stage 1-3 breast cancer and controls. No significant difference in SSBG and free estradiol-17 beta fraction as well as free estrogen index was established between patients and controls. In the patient group, a direct correlation was established between free estradiol-17 beta fraction level and that of mature T-cells expressing CD3 antigen and between SSBG level, on the one hand, and total level of T-cells (CD7 antigen) and that of T-suppressors (CD8 antigen-containing cytotoxic lymphocytes), on the other.