Publications by authors named "Saveen Giri"
Article Synopsis
- - Mutations in the DNAJB6 gene are linked to limb girdle muscular dystrophy type D1 (LGMD D1), a condition that results in progressive muscle weakness and specific muscle damage characteristics.
- - Researchers created a zebrafish model with a loss of Dnajb6 to study its effects, discovering that the absence of this gene leads to late-onset muscle weakness without major autophagy or myofibril issues, but with noticeable mitochondrial damage.
- - This study highlights the connection between DNAJB6 loss and mitochondrial defects in muscle, offering insights into LGMD D1 and a potential platform for testing new treatments.
Phosphoinositides are a minor group of membrane-associated phospholipids that are transiently generated on the cytoplasmic leaflet of many organelle membranes and the plasma membrane. There are seven functionally distinct phosphoinositides, each derived via the reversible phosphorylation of phosphatidylinositol in various combinations on the inositol ring. Their generation and termination is tightly regulated by phosphatidylinositol-kinases and -phosphatases.
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