Immunohaemostasis and the significance of immune reactions in the regulation of blood coagulation.

Introduction: This study was conducted to determine the specific features of the mutual influence of the immune and haemostatic systems in immunohaemostasis, the role of immune reactions in the regulation of blood coagulation, and the efficacy of modern methods of treating thrombosis and bleeding.

Methods: The study analysed relevant scientific sources on immunology and haematology and identified the specific features of the blood clotting process and the role of immune reactions in it.

Results: The study found that the immune system influences the haematological system through the interaction of blood clotting factors, platelets, plasminogen, endothelial cells with immune cells.

Genome Studies in Four Species of L. (Asteraceae) Using Satellite DNAs as Chromosome Markers.

The taxonomically challenging genus L. (Asteraceae) includes lots of medicinal species characterized by their high morphological and karyological variability. For the first time, a repeatome analysis of a valuable medicinal plant L.

Modulation of GABA release by 5-HT receptors: An interplay with AMPA-receptors and voltage-gated Ca channels.

Obesity has become a worldwide health challenge and commonly results from the intake of more calories than the body requires. The brain represents the master controller of food intake and as such has been the target of obesity medications. However, key mechanisms of druggable targets remain to be defined.

Encouraging pro-environmental behavior: Do testimonials by experts work?

Using non-pecuniary interventions to motivate pro-environmental behavior appeals to program administrators seeking cost-effective ways to increase adoption of environmental practices. However, all good-intended interventions should not be expected to be effective and reporting when interventions fail is as important as documenting their successes. We used a framed field experiment with 308 adults from the Mid-Atlantic in the United States to test the effectiveness of an expert testimonial in encouraging adoption of native plants in residential settings.

Deep learning enables automated MRI-based estimation of uterine volume also in patients with uterine fibroids undergoing high-intensity focused ultrasound therapy.

Background: High-intensity focused ultrasound (HIFU) is used for the treatment of symptomatic leiomyomas. We aim to automate uterine volumetry for tracking changes after therapy with a 3D deep learning approach.

Methods: A 3D nnU-Net model in the default setting and in a modified version including convolutional block attention modules (CBAMs) was developed on 3D T2-weighted MRI scans.

Simplified intravoxel incoherent motion DWI for differentiating malignant from benign breast lesions.

Background: To evaluate simplified intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for differentiating malignant versus benign breast lesions as (i) stand-alone tool and (ii) add-on to dynamic contrast-enhanced magnetic resonance imaging.

Methods: 1.5-T DWI data (b = 0, 50, 250, 800 s/mm) were retrospectively analysed for 126 patients with malignant or benign breast lesions.

[Long-term neurological outcomes in premature children with excitotoxic brain damage].

Objective: To establish the prognostic significance of a biomarker of excitotoxic brain damage (antibodies to the NR2 subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor) as a predictor of damage to the central nervous system (CNS) in preterm infants.

Material And Methods: 24 newborns with a gestational age of 24-33 weeks were examined with the determination of the level of antibodies to the NR2 subunit of the NMDA glutamate receptor on the 21st day of life.

Results: In the course of the study, it was found that the level of antibodies to the NR2 subunit of the NMDA glutamate receptor on the 21st day of life, in combination with the level of cord blood lactate and the resistance of cerebral vessels on the 1st day of life, can be predictors of CNS damage in a premature baby at the age of 1 month of corrected age.

An impedimetric biosensor for COVID-19 serology test and modification of sensor performance via dielectrophoresis force.

Coronavirus disease 2019 (COVID-19) has caused significant global morbidity and mortality. The serology test that detects antibodies against the disease causative agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has often neglected value in supporting immunization policies and therapeutic decision-making. The ELISA-based antibody test is time-consuming and bulky.

Highly Efficient Capture and Quantification of the Airborne Fungal Pathogen Employing a Nanoelectrode-Activated Microwell Array.

In this study, we present a microdevice for the capture and quantification of spores, pathogenic agents of one of the most harmful infectious diseases of crops, stem rot. The early prognosis of an outbreak is critical to avoid severe economic losses and can be achieved by the detection of a small number of airborne spores. However, the current lack of simple and effective methods to quantify fungal airborne pathogens has hindered the development of an accurate early warning system.

THE INFLUENCE OF UNHEALTHY NEUROTICISM ON THE PECULIARITIES OF PERSONAL DECISION MAKING.

Objective: The aim: To determine the influence of unhealthy neuroticism (the high level of personal neuroticism) on the properties of the decision-making process, to identify the differences in the decision-making process features of persons with high and low levels of neuroticism.

Patients And Methods: Materials and methods: A comparative design was used with two contrasting groups, which differed in the level of neuroticism. Causal relationships were defined using one-way analysis of variance (ANOVA).

NEUROTIC CONDITIONS: PROBLEM, DIAGNOSIS, CORRECTION BY COGNITIVE-BEHAVIOR THERAPY.

Objective: The aim: To identify the relationship between neurotic states and hardiness as an indicator of mental health, to explore the possibility of using the cognitive-behavior therapy techniques to correct neurotic states in young people.

Patients And Methods: Materials and methods: The methods "Clinical questionnaire for the detection and evaluation of neurotic conditions" (K. Yakhin, D.

Efficacy of ultrasound-guided high-intensity focused ultrasound (USgHIFU) for uterine fibroids: an observational single-center study.

Introduction: To evaluate treatment response of uterine fibroids after ultrasound guided high-intensity focused ultrasound (USgHIFU) with a special focus on fibroid size and characterization based on Funaki classification scheme, as well as clinical response to treatment of leading fibroid-associated symptoms.

Materials And Methods: Uterine fibroids treated by USgHIFU were assigned to Funaki type 1-3 based on T2-w-MRI. Differences in size, non-perfused volume ratio (NPVR) and volume reduction over time were determined using T1-/T2-w MRI sequences and contrast-enhanced sonography.

US-guided high-intensity focused ultrasound (HIFU) of abdominal tumors: outcome, early ablation-related laboratory changes and inflammatory reaction. A single-center experience from Germany.

Introduction: High-intensity focused ultrasound (HIFU) is an innovative noninvasive procedure for local ablation of different benign and malignant tumors. Preliminary data of animal studies suggest an ablation-associated immune response after HIFU that is induced by cell necrosis and release of intracellular components. The aim of this study is to evaluate if a HIFU-induced early sterile inflammatory reaction is initiated after ablation of uterine fibroids (UF) and pancreatic carcinoma (PaC) which might contribute to the therapeutic effect.

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.

Background: Vaginal adenocarcinomas (VAC) are most often reported after intrauterine exposition to diethylstilbestrol (DES). Rarely, VACs are reported as a malignant transformation of vaginal adenosis or endometriosis, in the context of chromosomal abnormalities or malformations of the uterus or the vagina. VACs without DES exposition have a poor prognosis and a significantly worse outcome compared to vaginal squamous cell carcinomas or DES-associated VACs.

[Comparative analysis of thoracoscopic and open thymectomy for thymoma stage I-II].

Objective: To improve the short-term postoperative outcomes in patients with thymoma stage I-II by using of thoracoscopic thymectomy (VATS TE) and to compare this technique with open (OTE) thymectomy.

Material And Methods: A retrospective analysis included 98 patients who had undergone surgery for thymoma stage I and II for the period from January 2001 to December 2019. VATS TE (main group) was performed in 53 (54.

TBK1 and TNFRSF13B mutations and an autoinflammatory disease in a child with lethal COVID-19.

Among children, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are typically mild. Here, we describe the case of a 3.5-year-old girl with an unusually severe presentation of coronavirus disease (COVID-19).

[Outcomes of minimally invasive surgery for mediastinal neurogenic tumors].

Objective: To improve postoperative outcomes in patients with mediastinal neurogenic tumors by using of minimally invasive surgical approaches.

Material And Methods: A retrospective analysis included 108 patients who underwent surgery for mediastinal neurogenic tumors for the period 2001-2019. Short-term outcomes of conventional and minimally invasive (VATS, supraclavicular approach and their combination with laminectomy) surgeries were analyzed.

Ultrasound-assisted magnetic nanoparticle-based gene delivery.

Targeted gene delivery is important in biomedical research and applications. In this paper, we synergistically combine non-viral chemical materials, magnetic nanoparticles (MNPs), and a physical technique, low-intensity pulsed ultrasound (LIPUS), to achieve efficient and targeted gene delivery. The MNPs are iron oxide super-paramagnetic nanoparticles, coated with polyethyleneimine (PEI), which makes a high positive surface charge and is favorable for the binding of genetic materials.

Impact of low-intensity pulsed ultrasound on the growth of Schizochytrium sp. for omega-3 production.

Schizochytrium sp. is a microalga that is known for its high content of oils or lipids. It has a high percentage of polyunsaturated fatty acids in the accumulated oil, especially docosahexaenoic acid (DHA).

G protein-coupled receptor binding and pharmacological evaluation of indole-derived thiourea compounds.

Four 2-(1H-indol-3-yl)ethylthiourea derivatives were prepared by condensation of 2-(1H-indol-3-yl)ethanamine with the corresponding aryl/alkylisothiocyanates in a medium-polarity solvent. Their structures were confirmed by spectral techniques, and the molecular structure of 3 was determined by X-ray crystal analysis. For all derivatives, the binding affinities at the 5-HT and 5-HT receptors, as well as their functional activities at the 5-HT and D receptors, were determined.

Reclaimed water and food production: Cautionary tales from consumer research.

Reclaimed water has been identified as a viable and cost-effective solution to water shortages impacting agricultural production. However, lack of consumer acceptance for foods irrigated with reclaimed and treated water remains one of the greatest hurdles for widespread farm-level adoption. Using survey data from 760 participants in the mid-Atlantic region of the U.

A Review of Low-Intensity Pulsed Ultrasound for Therapeutic Applications.

Ultrasound therapy has a long history of novel applications in medicine. Compared to high-intensity ultrasound used for tissue heating, low-intensity ultrasound has drawn increasing attention recently due to its ability to induce therapeutic changes without biologically significant temperature increase. Low-intensity pulsed ultrasound (LIPUS) is a specific type of ultrasound that delivers at a low intensity and outputs in the mode of pulsed waves.