Extracorporeal membrane oxygenation in trauma patient in France: A retrospective nationwide registry.

Background: Indications for Veno-venous (VV) or veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) after trauma rely on poor evidence. The main aims were to describe the population of trauma patients requiring either VV or VA ECMO and report their clinical management and outcomes.

Methods: An observational multicentre retrospective study was conducted in 17 Level 1 trauma centres in France between January 2010 and December 2021.

An innovative device for in vivo and in vitro study of fragrance evaporation after application on skin or model surfaces.

An original device has been developed to measure perfume release in the air above a surface. This device has proven its originality, effectiveness, and repeatability both in vitro on different types of model surfaces and in vivo directly on the skin of the forearm of volunteers. A perfume composed of eight fragrance molecules in ethanol was used to measure evaporation in the headspace with solid phase microextraction (SPME) and gas chromatography analysis.

CD206 macrophages are relevant non-invasive imaging biomarkers and therapeutic targets in experimental lung fibrosis.

Background: Interstitial lung diseases (ILDs) include a large number of diseases associated with progressive pulmonary fibrosis (PPF), including idiopathic pulmonary fibrosis (IPF). Despite the rarity of each of the fibrotic ILDs individually, they cumulatively affect a considerable number of patients. PPF is characterised by an excessive collagen deposition leading to functional decline.

Topical pickering emulsion versus classical excipients: A study of the residual film on the human skin.

The interest in Pickering emulsions is based on the possibility of replacing classical emulsifiers with solid particles. These emulsions are very attractive in the pharmaceutical field for their stability virtues and as a vehicle to deliver active ingredients. The study aimed to analyze the properties of the residual film of the Pickering emulsions on the human skin compared to conventional systems.

Fragrance in dermocosmetic emulsions: From microstructure to skin application.

Fragrance is added to almost all dermocosmetic emulsions, as it has been found to be a key driver in consumer choice and contributes to the perception of product performance. Fragrance is a complex mixture of odorant chemicals at different concentrations. When incorporated into a formulation, the individual fragrance chemicals partition between the emulsion phases depending on their physicochemical properties, which can impact the structure, stability, texture and odour of the final product.

Understanding of the residual odour of fatty esters used as emollient in cosmetic products.

Objective: Fatty esters are known for their versatility, but in addition to their performance as emollients, emulsifiers, solubilizers, or dispersing agents, they have to meet more and more criteria to be used in cosmetic products. Thus, their olfactory characteristics are expected to be as neutral as possible. However, despite a step of deodorization during the synthesis of fatty esters, a residual odour is currently still perceived at the end of the process.

The FibromiR miR-214-3p Is Upregulated in Duchenne Muscular Dystrophy and Promotes Differentiation of Human Fibro-Adipogenic Muscle Progenitors.

Fibrosis is a deleterious invasion of tissues associated with many pathological conditions, such as Duchenne muscular dystrophy (DMD) for which no cure is at present available for its prevention or its treatment. Fibro-adipogenic progenitors (FAPs) are resident cells in the human skeletal muscle and can differentiate into myofibroblasts, which represent the key cell population responsible for fibrosis. In this study, we delineated the pool of microRNAs (miRNAs) that are specifically modulated by TGFβ1 in FAPs versus myogenic progenitors (MPs) by a global miRNome analysis.

A review of environmental odor quantification and qualification methods: The question of objectivity in sensory analysis.

For several years, various issues have up surged linked to odor nuisances with impacts on health and economic concerns. As awareness grew, recent development in instrumental techniques and sensorial analysis have emerged offering efficient and complementary approaches regarding environmental odor monitoring and control. While chemical analysis faces several obstacles, the sensory approach can help overcome them.

Association between previous health condition and outcome after cardiac arrest.

Introduction: Overall survival of patients with out-of-hospital cardiac arrest (OHCA) remains low, even in those with return of spontaneous circulation (ROSC). In addition to usual prognostic characteristics, patients' medical history may also influence their outcome. This study aimed to investigate the role of pre-arrest comorbidities on hospital survival, neurological outcome and mode of death in OHCA patients with successful ROSC.

Objective odor analysis of incidentally emitted compounds using the Langage des Nez® method: application to the industrial zone of Le Havre.

Environmental odor studies are usually done using two approaches: nuisance impact assessment and source identification. The latter may be done using chemical analysis or sensory analysis. While sensory analyses offer many advantages, they also face the main obstacle: odor nature description still uses conventional methods based on subjective evocations as odor descriptors.

Impact of the synergistic interaction between xanthan and galactomannan on the stickiness properties of residual film after application on a surface.

The objective was to investigate the influence of synergism between xanthan gum (X) and galactomannans (guar gum (G) and locust bean gum (L)) on the stickiness of the film formed after the application of polysaccharides on a surface. The adhesion of the film was evaluated using a texture analyzer. X, G, and L were examined in concentrated solutions (0.

Early abolition of cough reflex predicts mortality in deeply sedated brain-injured patients.

Background: Deep sedation may hamper the detection of neurological deterioration in brain-injured patients. Impaired brainstem reflexes within the first 24 h of deep sedation are associated with increased mortality in non-brain-injured patients. Our objective was to confirm this association in brain-injured patients.

Frequency, risk factors, and outcomes of non-occlusive mesenteric ischaemia after cardiac arrest.

Purpose: Mesenteric ischaemia after successfully resuscitated cardiac arrest (CA) has been insufficiently studied. We aimed to assess the frequency, risk factors, and outcomes of non-occlusive mesenteric ischaemia (NOMI) after CA.

Methods: We retrospectively included patients admitted to a CA centre with sustained return of spontaneous circulation between 2007 and 2017.

Impact of cigarette smoke on physical-chemical and molecular proprieties of human skin in an ex vivo model.

Background: This is a study about the skin ageing exposome, focusing on the effect of cigarette smoke. Human living skin explants (HSE) were exposed to cigarette smoke (CS) of two cigarettes for 2 hours using a custom-made exposure chamber, the Pollubox . Effects on the surface physico-chemistry and molecular properties of the skin were analyzed and reported for the first time.

Maternal Supplementation of Food Ingredient (Prebiotic) or Food Contaminant (Mycotoxin) Influences Mucosal Immune System in Piglets.

The early life period is crucial for the maturation of the intestinal barrier, its immune system, and a life-long beneficial host-microbiota interaction. The study aims to assess the impact of a beneficial dietary (short-chain fructooligosaccharides, scFOS) supplementation vs. a detrimental dietary environment (such as mycotoxin deoxynivalenol, DON) on offspring intestinal immune system developmental profiles.

Residual film formation after emulsion application: Understanding the role and fate of excipients on skin surface.

This study focuses on the fate of excipients contained in topical emulsions once applied on the skin. The aim was thus to develop a methodology to characterize the residue left on the skin shortly after emulsion application. To this end, both the role and the impact of the different excipients on the formation and properties of the residue left on the skin surface once a product is applied were investigated.

Complementary approaches to understand the spreading behavior on skin of O/W emulsions containing different emollientss.

The human skin is a very complex living tissue, in a permanent evolution and self-renewing by constant lipids secretion. The characterization of this biological material is a major concern in dermo-cosmetic and pharmaceutics fields. Understanding the skin interaction with its environment, during application of skincare products, is consequently of genuine interest to better control the different phenomena occurring.

Design of a Lipid-Coated Polymeric Material Mimic Human Skin Surface Properties: a Performing Tool to Evaluate Skin Interaction with Topical Products.

An original nonbiological skin model (NBSM) has been developed to mimSic skin surface properties. This skin model presents several improvements when compared to existing ones: it has a topography identical to that of skin and a lipid composition close to that of the skin face. This imparts to the model surface a physicochemistry similar to skin.

Sensory perception of textural properties of cosmetic Pickering emulsions.

Objective: The increasing interest for the Pickering emulsions is based on the possibility to replace classical emulsifiers by the solid particles. This approach is extremely attractive for the cosmetic field. But, the main difficulty is to obtain stable emulsions with appreciable skin feel.

Cadmium-Induced Renal Cell Toxicity Is Associated With MicroRNA Deregulation.

Cadmium is an environmental pollutant well known for its nephrotoxic effects. Nevertheless, mechanisms underlying nephrotoxicity continue to be elucidated. MicroRNAs (miRNAs) have emerged in recent years as modulators of xenobiotic-induced toxicity.

Caveolin-1 rs4730751 single-nucleotide polymorphism may not influence kidney transplant allograft survival.

Caveolin-1 is a protein (encoded by the CAV1 gene) supposedly harboring a protective effect against fibrosis. CAV1 rs4730751 single nucleotide polymorphism (SNP) AA genotype was initially associated with lower graft survival compared to non-AA. However, subsequent studies could not find the same effect.

Brazilian and French sensory perception of complex cosmetic formulations: a cross-cultural study.

Objective: Brazil and France are two major beauty markets worldwide. Despite this, there is not much cross-information on sensory analysis of cosmetic products between both population of these countries. The objective of this study was to compare the sensory perception of cosmetic formulations between Brazilian and French assessors and establish cross-culturally preferences.