Evaluating the Effects of Modified Windscreens on Organic Vapor Monitor Performance.

Passive sampling using diffusive samplers has become popular as a convenient means of occupational compliance sampling for volatile organic compounds (VOCs). However, diffusive samplers possess sensitivity limitations when sampling low concentrations and for short durations. To reduce these limitations, our research team has been developing a novel method of sample recovery called photothermal desorption (PTD), which uses high energy visible light pulses to desorb analytes from sampling media.

Muscle memory: myonuclear accretion, maintenance, morphology, and miRNA levels with training and detraining in adult mice.

Background: In the context of mass regulation, 'muscle memory' can be defined as long-lasting cellular adaptations to hypertrophic exercise training that persist during detraining-induced atrophy and may facilitate future adaptation. The cellular basis of muscle memory is not clearly defined but may be related to myonuclear number and/or epigenetic changes within muscle fibres.

Methods: Utilizing progressive weighted wheel running (PoWeR), a novel murine exercise training model, we explored myonuclear dynamics and skeletal muscle miRNA levels with training and detraining utilizing immunohistochemistry, single fibre myonuclear analysis, and quantitative analysis of miRNAs.

Elevated myonuclear density during skeletal muscle hypertrophy in response to training is reversed during detraining.

Myonuclei gained during exercise-induced skeletal muscle hypertrophy may be long-lasting and could facilitate future muscle adaptability after deconditioning, a concept colloquially termed "muscle memory." The evidence for this is limited, mostly due to the lack of a murine exercise-training paradigm that is nonsurgical and reversible. To address this limitation, we developed a novel progressive weighted-wheel-running (PoWeR) model of murine exercise training to test whether myonuclei gained during exercise persist after detraining.