Publications by authors named "Savannah F Spradlin"
Article Synopsis
- * There are over 55 types of riboswitches classified mainly by the ligands they bind, but the review introduces a new way to group them based on their mechanisms of action: "direct occlusion," "interdomain docking," and "strand exchange."
- * The review highlights the features and examples of these mechanisms while acknowledging that more research is needed on strand exchange, and it discusses the limitations of their proposed framework in understanding riboswitch function in gene regulation.
A key aspect in defining cell state is the complex choreography of DNA binding events in a given cell type, which in turn establishes a cell-specific gene-expression program. Here we wanted to take a deep analysis of DNA binding events and transcriptional output of a single cell state (K562 cells). To this end we re-analyzed 195 DNA binding proteins contained in ENCODE data.
View Article and Find Full Text PDF