A shift between mineral and nonmineral sources of iron and sulfur causes proteome-wide changes in .

Iron (Fe) and sulfur (S) are required elements for life, and changes in their availability can limit the ecological distribution and function of microorganisms. In anoxic environments, soluble Fe typically exists as ferrous iron [Fe(II)] and S as sulfide (HS). These species exhibit a strong affinity that ultimately drives the formation of sedimentary pyrite (FeS).

Arsenic Exposure Causes Global Changes in the Metalloproteome of .

Arsenic is a toxic metalloid with differential biological effects, depending on speciation and concentration. Trivalent arsenic (arsenite, As) is more toxic at lower concentrations than the pentavalent form (arsenate, As). In , the proteins encoded by the operon are the major arsenic detoxification mechanism.