An 8-aminoquinoline-naphthyl copper complex causes apoptotic cell death by modulating the expression of apoptotic regulatory proteins in breast cancer cells.

Breast cancer is one of the most common cancers globally and a leading cause of cancer-related deaths among women. Despite the combination of chemotherapy with targeted therapy, including monoclonal antibodies and kinase inhibitors, drug resistance and treatment failure remain a common occurrence. Copper, complexed to various organic ligands, has gained attention as potential chemotherapeutic agents due to its perceived decreased toxicity to normal cells.

Visible-Light-Driven Stereoselective Annulation of Alkyl Anilines and Dibenzoylethylenes via Electron Donor-Acceptor Complexes.

A catalyst-free, stereoselective visible-light-driven annulation reaction between alkenes and ,-substituted dialkyl anilines for the synthesis of substituted tetrahydroquinolines is presented. The reaction is driven by the photoexcitation of an electron donor-acceptor (EDA) complex, and the resulting products are obtained in good to high yields with complete diastereoselectivity. Mechanistic rationale and photochemical characterization of the EDA-complex are provided.

Control of crystal structure using temperature and time.

Three novel crystal structures were obtained from iron(III) acetylacetonate and 2,6-pyridinedicarboxylic acid. The structures elucidated were found to be dependent on the temperature and length of time allowed for the reaction. The product of the reaction between iron(III) acetylacetonate and 2,6-pyridinedicarboxylic acid in acetonitrile at room temperature is [FeCHNO]·CHCN, (I).

Supramolecular metallogels constructed from carboxylate gelators.

Serendipity still plays a role in gel discovery as the prediction of gel formation is difficult. This work explores the role of ligand, metal salt, solvent, and temperature in the formation of a low molecular mass carboxylate iron(iii) system. The influence of each component is discussed.