Markers of Environmental Enteric Dysfunction are Associated with Poor Growth and Developmental Outcomes among Young Children in Lusaka, Zambia.

Objective: To examine cross-sectional relationships between biomarkers of environmental enteric dysfunction (EED), an acquired subclinical condition of the small intestine, and anthropometric and developmental outcomes among children in Lusaka, Zambia.

Study Design: Serum samples were collected from 240 children aged 27 to 35 months enrolled in a cluster-randomized trial assessing the effects of growth charts and small-quantity lipid-based nutrient supplements on linear growth. Samples were analyzed using the 11-plex Micronutrient and EED Assessment Tool, which incorporates 2 biomarkers of EED, namely intestinal fatty acid-binding protein (I-FABP), a marker of epithelial damage, and soluble CD14 (sCD14), a marker of microbial translocation.

Predictors of Stunting and Pathway Analysis for Linear Growth among Children Aged Two to Three Years after a Trial of Small-Quantity Lipid-Based Nutrient Supplements and Home-Installed Growth Charts in Three Districts in Zambia.

Background: Globally, 148 million children aged <5 y are stunted, with risk factors varying by context. Our "Impact of Growth Charts and Nutritional Supplements on Child Growth in Zambia" (ZamCharts) trial observed persistently high rates of stunting in all treatment groups after 18-mo of intervention with monthly distributions of small-quantity lipid-based nutrient supplements (SQ-LNS) and/or installation of a wall-mounted growth chart in children's homes.

Objectives: We sought to identify determinants of stunting and height-for-age z-score in children aged 27-36 mo who participated in the ZamCharts endline survey (n = 1911).

The impact of home-installed growth charts and small-quantity lipid-based nutrient supplements (SQ-LNS) on child growth in Zambia: a four-arm parallel open-label cluster randomised controlled trial.

Background: Childhood stunting remains common in many low-income settings and is associated with increased morbidity and mortality, as well as impaired child development.

Methods: The main objective of the study was to assess whether home-installed growth charts as well as small-quantity lipid-based nutrient supplements (SQ-LNS) can reduce growth faltering among infants. All caregivers of infants between 2 and 10 months of age at baseline, and at least 6 months old at the beginning of the interventions, in 282 randomly selected enumeration areas in Choma, Mansa and Lusaka districts in Zambia were invited to participate in the study.

Feasibility of caregiver-administered anthropometric measurements of children under age 5: evidence from Zambia.

Background: Accurate measurement of children's anthropometry is of central importance for the assessment of nutritional status as well as for the evaluation of nutrition-specific interventions. Social distancing requirements during the recent Covid-19 pandemic made administration of standard assessor-led measurement protocols infeasible in many settings, creating demand for alternative assessment modalities.

Objective: To assess the feasibility and reliability of caregiver-administered anthropometric assessments of children under age 5.