Background: The application of splints is one of the most used methods to prolong the life span of peripheral intravenous cannulation (PIVC).
Objective: To assess the effect of splint application on the functional duration of PIVC in neonates.
Methods: This systematic review and meta-analysis identified, appraised, and synthesized available evidence from randomized and quasi-randomized controlled trials (RCT) related to the effects of splint application compared to no splinting on the functional duration of PIVC and its associated complications in term and preterm neonates.