Ocular Manifestations of Coronavirus Disease 2019: A Hospital-Based Prospective Study at a Coronavirus Disease Dedicated Tertiary Center.

Purpose: To investigate ophthalmic manifestations in coronavirus disease 2019 (COVID-19) patients admitted to a designated COVID-19 center in Northern India during the period from April 13, 2020, to April 13, 2022. This aims to provide a comprehensive understanding of ocular involvement in the context of the pandemic.

Methods: This is a hospital-based prospective observational study.

Structural and mechanical properties of individual human telomeric G-quadruplexes in molecularly crowded solutions.

Recent experiments provided controversial observations that either parallel or non-parallel G-quadruplex exists in molecularly crowded buffers that mimic cellular environment. Here, we used laser tweezers to mechanically unfold structures in a human telomeric DNA fragment, 5'-(TTAGGG)4TTA, along three different trajectories. After the end-to-end distance of each unfolding geometry was measured, it was compared with PDB structures to identify the best-matching G-quadruplex conformation.