Publications by authors named "Saul Vazquez-Reina"

Non-viral delivery systems are generally of low efficiency, which limits their use in gene therapy and editing applications. We previously developed a technology termed glycosaminoglycan (GAG)-binding enhanced transduction (GET) to efficiently deliver a variety of cargos intracellularly; our system employs GAG-binding peptides, which promote cell targeting, and cell penetrating peptides (CPPs), which enhance endocytotic cell internalization. Herein, we describe a further modification by combining gene delivery and magnetic targeting with the GET technology.

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  • Many antibiotic resistance genes are found alongside metal resistance genes, implying that high metal concentrations may promote antibiotic resistance.
  • The use of metals like copper and zinc in farming can enhance the risk of antibiotics resistance in animals.
  • A mathematical model has been developed to predict the minimal concentrations of metals that co-select for antibiotic resistance, revealing specific thresholds for metals like copper, zinc, and mercury based on their toxicity.
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Nanoparticles (NPs) are increasingly being developed as biomedical platforms for drug/nucleic acid delivery and imaging. However, in biological fluids, NPs interact with a wide range of proteins that form a coating known as protein corona. Coronae can critically influence self-interaction and binding of other molecules, which can affect toxicity, promote cell activation, and inhibit general or specific cellular uptake.

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Consumption of rice and rice products can be a significant exposure pathway to inorganic arsenic (iAs), which is a group 1 carcinogen to humans. The UK follows the current European Commission regulations so that iAs concentrations must be < 0.20 mg kg in white (polished) rice and <0.

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  • A study on the legume Medicago truncatula revealed the accumulation and excretion patterns of riboflavin (Rbfl) and its derivatives under different iron deficiency conditions.
  • High-resolution mass spectrometry identified three new flavin derivatives in the roots, along with Rbfl, with root accumulation being influenced by the presence of calcium carbonate (CaCO3).
  • The research also noted that while Rbfl and its derivatives showed varying levels of accumulation and export, there was no significant correlation between Rbfl levels and two other related enzymes, highlighting the complex interactions within root physiology.
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