Psychiatric neuroimaging at a crossroads: Insights from psychiatric genetics.

Thanks to methodological advances, large-scale data collections, and longitudinal designs, psychiatric neuroimaging is better equipped than ever to identify the neurobiological underpinnings of youth mental health problems. However, the complexity of such endeavors has become increasingly evident, as the field has been confronted by limited clinical relevance, inconsistent results, and small effect sizes. Some of these challenges parallel those historically encountered by psychiatric genetics.

A Qualitative Study of Maternal Perceptions of Stress and Parenting During Early Childhood.

Objective: Exposure to maternal stress in early childhood can increase risk for learning and behavior challenges. We sought to gain in-depth understanding of how mothers perceive stressors to impact child wellbeing and identify mothers' strategies for navigating stressors with their young children.

Methods: We recruited English- and Spanish-speaking mothers from a primary care clinic serving predominantly publicly insured children.

Perinatal and early childhood biomarkers of psychosocial stress and adverse experiences.

The human brain develops through a complex interplay of genetic and environmental influences. During critical periods of development, experiences shape brain architecture, often with long-lasting effects. If experiences are adverse, the effects may include the risk of mental and physical disease, whereas positive environments may increase the likelihood of healthy outcomes.