Publications by authors named "Saul S Gilbert"

The endogenous melatonin onset in dim light (DLMO) is a marker of circadian phase that can be used to appropriately time the administration of bright light or exogenous melatonin in order to elicit a desired phase shift. Determining an individual's circadian phase can be costly and time-consuming. We examined the relationship between the DLMO and sleep times in 16 young healthy individuals who slept at their habitual times for a week.

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Temperature and sleep are interrelated processes. Under normal environmental conditions, the rhythms of core body temperature Tc and sleep propensity vary inversely across the day and night in healthy young adults. Although this relationship has drawn considerable interest, particularly in recent years, it is still not known whether this relationship is causative or merely coincidental.

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Body temperature regulation is associated with changes in sleep propensity; therefore, sleep research often necessitates concomitant assessment of core and skin surface temperatures. Attachment to thermistors may limit the range of movement and comfort, introducing a potential confound that may prolong sleep initiation or increase wakefulness after sleep onset. It has been suggested that contact thermometry may artificially increase temperatures due to insulation.

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Exercise effects on sleep in fit healthy people have been difficult to determine because their sleep is close to optimal, leaving little room for improvement. Another method for assessing exercise effects on sleep is to significantly reduce the degree of activity in highly active people. Fifteen trained athletes who exercised daily at a moderate to high intensity were employed.

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Study Objectives: The sleep promoting effects of the sedative-hypnotics, melatonin and temazepam, have been associated with a decline in core body temperature (Tc). To determine whether changes in body temperature are a general feature of sedative-hypnotics, the present study compared the sleep inducing, core and peripheral temperature effects of melatonin, with those of zopiclone.

Design: Subjects were supine from 08:00-21:30 h and received melatonin, zopiclone or placebo at 14:00 h.

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