Publications by authors named "Saul Landaverde"

Misexpression of the E3 ubiquitin ligase gene UBE3A is thought to contribute to a range of neurological disorders. In the context of Dup15q syndrome, additional genomic copies of UBE3A give rise to the autism, muscle hypotonia and spontaneous seizures characteristics of the disorder. In a Drosophila model of Dup 15q syndrome, it was recently shown that glial-driven expression of the UBE3A ortholog dube3a led to a "bang-sensitive" phenotype, where mechanical shock triggers convulsions, suggesting glial dube3a expression contributes to hyperexcitability in flies.

View Article and Find Full Text PDF

Misexpression of the E3 ubiquitin ligase is thought to contribute to a range of neurological disorders. In the context of Dup15q syndrome, excess genomic copies of is thought to contribute to the autism, muscle tone and spontaneous seizures characteristic of the disorder. In a model of Dup 15q syndrome, it was recently shown glial-driven expression of the ortholog led to a "bang-sensitive" phenotype, where mechanical shock triggers convulsions, suggesting glial expression contributes to hyperexcitability in flies.

View Article and Find Full Text PDF