Distinct clinicopathological features in metanephric adenoma harboring BRAF mutation.

mutation recently has been reported in metanephric adenoma. We sought to determine the clinical and morphologic features of -mutated metanephric adenoma and to correlate mutation with BRAF V600E immunohistochemical staining results. A series of 48 metanephric adenomas and 15 epithelial-predominant nephroblastomas were analyzed for the occurrence of mutation ( V600E/V600E complex, V600D, V600K and V600R) using the BRAF RGQ PCR kit (Qiagen).

Testicular cancer: The usage of central review for pathology diagnosis of orchiectomy specimens.

Background: Radical orchiectomy specimens present a unique set of challenges for pathology assessment owing to their rarity and complexity. This study compares second opinion pathology reports generated at a single, large academic institution to primary reports from outside hospitals.

Methods: A database search was conducted for orchiectomy cases that were sent to our institution for management of testicular cancer from 2014 to 2015.

Primary mucinous adenocarcinoma of the female urethra: a contemporary clinicopathologic analysis.

Primary mucinous adenocarcinoma of the female urethra is very rare and may lead to both diagnostic and therapeutic challenges. Although primary mucinous adenocarcinoma of the prostate and prostatic urethra has been well characterized in men, this is the largest clinicopathologic study to date of primary mucinous adenocarcinoma of the female urethra. A search was made through the files of 2 major academic institutions for cases of confirmed primary mucinous adenocarcinoma arising from the female urethra.