Publications by authors named "Sau Mei Tse"
Article Synopsis
- - The study aimed to compare the effectiveness of romosozumab (ROMO) and denosumab (DEN) in increasing spine bone mineral density (BMD) in patients using long-term glucocorticoids, specifically those on prednisolone. - Results showed that after 12 months, ROMO significantly increased spine BMD by 7.3% compared to 2.3% with DEN, and this trend continued for both groups at 24 months, although ROMO still had greater gains. - While both treatments were effective, ROMO led to better results for spine BMD, but patients on ROMO reported more injection site reactions.
Article Synopsis
- The study investigated how SARS-CoV2 infection affects systemic lupus erythematosus (SLE) flare-ups in patients who had COVID-19 during 2022.
- Researchers compared 91 SLE patients with COVID-19 to 182 matched SLE patients without the virus, focusing on SLE flares within 90 days post-infection.
- Results showed that 17.6% of SARS-CoV2-infected SLE patients experienced flares, significantly higher than the 5.5% in non-infected patients, indicating a strong association between COVID-19 and SLE flare-ups.
The relationship between viral infection and onset of autoimmune diseases such as systemic lupus erythematosus remains uncertain. During the COVID-19 pandemic, organ-specific and multisystemic autoimmune phenomena temporally related to the viral infection have been described. Immune dysregulation triggered by the SARS-CoV-2 virus leading to hyperactivation of both the innate and adaptive immune systems contributes to the excessive production of pro-inflammatory cytokines, autoantibodies, and subsequent autoimmune manifestations.
View Article and Find Full Text PDFTo study the relationship of serum PCSK9 and disease activity and major adverse cardiovascular events (MACEs) in systemic lupus erythematosus (SLE). Consecutive patients who fulfilled ≥ 4 ACR criteria for SLE and consented for a biomarker study in 2009-2013 were included. Stored serum samples were assayed for PCSK9.
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- The study focused on understanding how common herpes zoster (HZ) infections are among patients with rheumatic diseases and identifying related risk factors.
- A total of 1,479 patients were analyzed, with a notable prevalence of HZ found particularly in those with systemic lupus erythematosus (SLE) and inflammatory myopathies, as they experienced reactivation at higher rates.
- Key findings indicated that younger patients with SLE, lower serum albumin/globulin levels, and those using immunosuppressive medications were more likely to experience HZ infections.
Objectives: To study the rate of SARS-CoV-2 vaccination and post-vaccination disease flares in patients with systemic lupus erythematosus (SLE).
Methods: Patients who fulfilled ≥ 4 of the ACR criteria for SLE were identified and their SARS-CoV-2 vaccination status was traced. Flares of SLE at 6-week post-vaccination were reviewed retrospectively.
Background: The fracture risk assessment tool has been widely used to stratify the 10-year fracture risk to guide therapy. Using the actual fracture data of a 10-year longitudinal cohort of older patients with systemic lupus erythematosus, we reported an underestimation of the tool in predicting major symptomatic osteoporotic fractures. Treatment of osteoporosis in systemic lupus erythematosus should not be based on fracture risk estimation alone.
View Article and Find Full Text PDFTrend of Survival of a Cohort of Chinese Patients With Systemic Lupus Erythematosus Over 25 Years.
Front Med (Lausanne)
September 2020
To revisit the trend of survival of systemic lupus erythematosus in a cohort of Chinese patients over 25 years. Patients who fulfilled the 1997 ACR criteria for SLE and were followed in our hospital since 1995 were included. Patients were stratified into two groups according to the year of diagnosis: (1) 1995-2004 and (2) 2005-2018.
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- The study investigates how common herpes zoster (shingles) is among patients with lupus nephritis receiving immunosuppressive treatments from 2004 to 2018.
- Out of 251 patients, 18% experienced herpes zoster reactivation within two years of treatment, with notable correlations to being newly diagnosed with renal disease and specific medication dosages.
- Despite the occurrences, no severe outcomes like death were reported, indicating that while herpes zoster is prevalent in this population, it remains unpredictable based on standard clinical indicators. *
Objectives: To study the effect of the metabolic syndrome (MetS) on organ damage and mortality in patients with SLE.
Methods: Consecutive patients who fulfilled ≥4 ACR criteria for SLE were assessed for the MetS in October 2010. The MetS was defined by the updated joint consensus criteria, using the Asian criteria for central obesity.
Article Synopsis
- The study investigates how often remission occurs in Chinese patients with systemic lupus erythematosus (SLE) and its impact on their health and quality of life (QOL).
- Out of 769 patients studied, only 8.3% achieved clinical remission for 5 years, while 16.8% reached complete remission for the same duration, with older patients showing better remission rates and less disease-related complications.
- Patients with at least 5 years of remission experienced less damage to their health and reported a significantly better quality of life compared to those who did not achieve long-term remission.
Objectives The objective of this paper is to study the time trend and risk factors of avascular bone necrosis (AVN) in patients with systemic lupus erythematosus (SLE). Methods Between 1999 and 2014, patients who fulfilled the ACR criteria for SLE and developed symptomatic AVN were identified from our cohort database and compared with those without AVN, matched for age, sex and SLE duration. The standardized incidence ratios (SIRs) of AVN in different SLE age groups were calculated from data derived from our hospital registry and population census.
View Article and Find Full Text PDFHydroxychloroquine Serum Concentrations and Flares of Systemic Lupus Erythematosus: A Longitudinal Cohort Analysis.
Arthritis Care Res (Hoboken)
September 2016
Objective: To study the relationship between serum hydroxychloroquine (HCQ) concentrations and flares of systemic lupus erythematosus (SLE) in a longitudinal cohort of patients.
Methods: Patients who fulfilled ≥4 American College of Rheumatology classification criteria for SLE and had been treated with HCQ for >6 months were studied. Blood was assayed for HCQ levels by tandem mass spectrometry.