[Ultrastructural characteristics of thyroid medullary carcinoma].

17 thyroid medullary carcinomas (TMC) were studied electron microscopically (EM). Two cell groups were revealed regardless of their histological structure: EM differentiated (with signs of C-cell differentiation) and non-differentiated (without these signs). There is no correlation between histological structure of the tumor and the degree of its EM differentiation.

[Histological variants of thyroid medullary carcinoma].

A total of 114 medullary carcinomas of the thyroid were studied clinically and histologically. Females and subjects aged over 40 years predominated among the patients (2-fold more than others). Five- and ten-year survival was 74 and 46.

[Spindle-cell variant of thyroid medullary carcinoma with favourable prognosis].

A case of a favourable outcome of spindle-cell medullary carcinoma of the thyroid is reported. Electron-microscopically, there was no correlation between histological and ultrastructural differentiation. The tumor consisted mainly of ultrastructurally differentiated cells with endocrine granules which may be the cause of the favourable prognosis.

[Status of the myocardial ventricles in thromboembolism of the pulmonary arteries and their branches (based on early autopsy material)].

Ventricle myocardium of 16 patients who had died from acute thromboembolism (TE) of the pulmonary arteries was studied. The most important factor in the development of myocardial alterations is the degree of a vascular occlusion by the thrombus. Chronic lung and heart diseases as well as patient age may considerably aggravate the structural changes of the cardiomyocytes.

[Changes in the dehydrogenase activity of the cardiomyocytes in experimental acute massive pulmonary embolism].

A study of the activity of SDG, LDG, NAD-D in several structures of the heart was carried out in acute compensated massive embolism of the pulmonary artery. TV-histophotometry demonstrated heterogeneity of metabolic processes in the myocardium in the control and experimental group. The animals with pulmonary artery embolism showed diverse hemodynamic changes in the lesser and greater circulation.

[Lesions of ventricular cardiomyocytes in experimental massive pulmonary embolism].

The damage of ventricular myocardial cells during acute experimental massive pulmonary embolism (MPE) was studied by light, polarization and electron microscopy on anaesthetized dogs. In cases, when MPE was followed by heart failure, the deep ir reversible damage of myofibrils took place, and the relative volume of myofibrils decreased in both ventricles. The damage of right ventricular myocardium, which works against increased postload during MPE, may be reason of right ventricular insufficiency.

[Clinico-experimental study of histoenzymological changes in the ventricular myocardium in pulmonary embolism].

The SDH and LDH activity in ventricular myocardium was studied in early autopsies of 16 patients, which died from acute pulmonary thromboembolism, and also in 17 dogs with experimental pulmonary embolism. In general the data of histoenzymological study of experimental and sectional material were identical. We revealed some factors, which correlated with low activity of catabolic enzymes in ventricular myocardium of the patients with pulmonary embolism: small volume of embolic occlusion (the thromboembolism of lobar and segmental pulmonary arteries); the presence of prior chronic cardiopulmonary disease; the advanced age and the female sex.

[Structural-metabolic changes in the ventricular myocardium in massive experimental pulmonary embolism].

A comparative study of hemodynamic and structural-metabolic changes in myocardium of right (RV) and left (LV) ventricles by compensative massive pulmonary embolism (MPE) and decompensated MPE was made in 29 mongrel dogs. By decompensated MPE the histoenzymological and ultrastructural methods reveal changes in RV which are not adequate to its high hemodynamic load: the catabolic enzymes activity decreases, the numeral density of mitochondrial profiles decreases too, the fraction of damaged mitochondria increases. By decompensated MPE the myocardial metabolism shifts from catabolic to biosynthetic processes, the activity of NADP.

[The functional-morphological state of the myocardium in experimental massive embolism of the pulmonary artery].

A comparative study of hemodynamic and structural-metabolic changes in the myocardium of the right (RV) and left ventricles (LV) in acute massive pulmonary artery embolism was made in 19 mongrel dogs. In the control group the activity of SDH, MDH, GDH, NADH-DH in LV were higher than in RV. The numeral density and relative area of mitochondrial profile surface in LV was higher that in RV.