Highly Efficient Synthesis of Chalcones from Poly Carbonyl Aromatic Compounds Using BF3-Et2O via a Regioselective Condensation Reaction.

A new, simple, highly efficient method for the synthesis of different types of carbonyl chalcones through a regioselective condensation reaction of appropriate 5-acetyl-2-hydroxybenzaldehyde with various substituted acetophenones and 4-hydroxyisothalaldehyde with various substituted aldehydes using BF3-Et2O as a reagent is described.