Publications by authors named "Satya Narayana Murthy Chilla"
Reactive extrusion and magnesium (II) -heterocyclic carbene catalyst are successfully employed in continuous polylactide synthesis. The possibility of using six-membered -heterocyclic carbene adducts to act as efficient catalysts towards the sustainable synthesis of poly(l-lactide) through ring-opening polymerization of l-lactide (LA) is first investigated in bulk batch reactions. Under optimized solvent-free conditions, polylactide (PLA) of moderate to high molecular weights and excellent optical activities are successfully achieved.
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- - Non-invasive imaging of human beta cell mass is challenging, but research focused on a peptide called P88 that targets the biomarker FXYD2γa may offer a solution.
- - The researchers created a new MRI contrast agent by linking P88 with DOTA and GdCl₃, called Gd-DOTA-P88, and tested it in mice implanted with human beta cell line EndoC-βH1.
- - Results showed that Gd-DOTA-P88 accumulates significantly in the beta cell xenografts compared to background tissue, suggesting it could be a valuable tool for non-invasive imaging of human beta cells in future studies.
A new facile synthetic strategy was developed to prepare bifunctional monophosphinic acid Ln-DOTA derivatives, Gd-DO2AGAP and Gd- DO2AGAP. The relaxivities of the Gd-complexes are enhanced compared to Gd-DOTA. Monophosphinic acid arm of these Gd-complexes affords enhancement of inner sphere water exchange rate due to its steric bulkiness.
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