Publications by authors named "Satwinderjeet Kaur"

Iris kashmiriana belongs to the family Iridaceae and is an important endemic medicinal plant of Kashmir. The current study was designed to determine the phytoconstituents, antioxidant, and cytotoxic potential of ethyl acetate (IRK-ETH) and methanol (IRK-MTH) extracts of Iris kashmiriana flowers. IRK-MTH extract demonstrated maximum radical scavenging activity in DPPH, ABTS, and Superoxide anion radical antioxidant assays with IC values of 73.

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Endogenous release of HSO during the enzymatic oxidation of sulfur containing amino acids in mitochondria or insufficiency of sulfite oxidase results in the accumulation of sulfite and thiosulfate in biological fluids affecting mitochondrial homeostasis of brain mitochondria associated with serious clinical symptoms related to neurological disorders. The red fluorescent probe MGQ undergoes self-assembly in water and reveals aggregation induced quenching of fluorescence. MGQ reveals 143-fold and 179-fold increases in fluorescence intensity at 645 nm, respectively, in the presence of HSA and BSA and does not significantly differentiate between two albumins.

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Article Synopsis
  • * Two fractions, TdRM-1 and TdRM-2, were separated from the crude extract, with TdRM-2 showing notably higher antioxidant activity and effective inhibition of cancer cell proliferation in various tests.
  • * The findings highlight TdRM-2's ability to induce apoptosis in cancer cells, suggesting that the root extracts have considerable therapeutic promise due to their rich phytochemical composition and biological effects.
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The interplay of ESIPT+TICT mechanisms in 1,8-naphthalimide-hydroxyquinoline (NQ-OH) molecular rotor were reported for the near-IR 'turn-on' emission (λ 600 nm) and ratiometric (A/A) absorbance-based detection of Al ions in aqueous medium and live cells which were supported by NMR, IR and CV techniques. The limit of detection (LOD) for Al ions is 100 nM and 14.57 nM.

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Over the past decade, a plethora of research has illuminated the multifaceted roles of hydrogen sulfide (HS) in plant physiology. This gaseous molecule, endowed with signaling properties, plays a pivotal role in mitigating metal-induced oxidative stress and strengthening the plant's ability to withstand harsh environmental conditions. It fulfils several functions in regulating plant development while ameliorating the adverse impacts of environmental stressors.

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Aldehyde dehydrogenase 1A1 (ALDH1A1) is an isoenzyme that catalyzes the conversion of aldehydes to acids. However, the overexpression of ALDH1A1 in a variety of malignancies is the major cause of resistance to an anti-cancer drug, cyclophosphamide (CP). CP is a prodrug that is initially converted into 4-hydroxycyclophosphamide and its tautomer aldophosphamide, in the liver.

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A naphthalimide based chemosensor (NPG), containing 1,8-naphthalimide as a fluorophore unit and pentaethylene glycol as a binding unit, has been used for the detection of Pd ions in 50% HEPES buffer-DMSO (pH 7.2) solution. The NPG showed aggregation induced emission enhancement (AIEE) properties in HO-DMSO binary mixtures (0-90%) and the CIE plot of NPG in DMSO has = 0.

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Biologically active secondary metabolites, essential oils, and volatile compounds derived from medicinal and aromatic plants play a crucial role in promoting human health. Within the large family Asteraceae, the genus consists of approximately 500 species. species have a rich history in traditional medicine worldwide, offering remedies for a wide range of ailments, such as malaria, jaundice, toothache, gastrointestinal problems, wounds, inflammatory diseases, diarrhoea, menstrual pains, skin disorders, headache, and intestinal parasites.

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Article Synopsis
  • * Molecular docking studies confirm the PBI-SAH assemblies' inhibitory effects and suggest they could serve as a safe insecticide with a good balance of benefits to risks.
  • * This research marks the first instance of PBI-SAH assemblies effectively detecting chlorpyrifos and demonstrating AChE inhibitory activity, along with showing high insecticidal effectiveness against the pest Spodoptera litura.
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Pteris vittata L. is a terrestrial genus growing in moist, shady forests and on hillsides. The plant has considerable ethnomedicinal importance.

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Cyclophosphamide (CP) is one of the most widely used anticancer drugs for various malignancies. However, its long-term use leads to ALDH1A1-mediated inactivation and subsequent resistance which necessitates the development of potential ALDH1A1 inhibitors. Currently, ALDH1A1 inhibitors from different chemical classes have been reported, but these failed to reach the market due to safety and efficacy problems.

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In this report, we present our results on the recognition of multiple analytes using trisubstituted PDI-based chemosensors DNP and DNB in 50% HEPES buffered-CHCN solution. Upon the addition of Hg, DNB showed a decrease and increase in absorbance intensity at 560 and 590 nm, respectively, with a detection limit of 7.17 μM and bleaching of the violet color (de-butynoxy).

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The Cucurbitaceae family produces a class of secondary metabolites known as cucurbitacins. The eight cucurbitacin subunits are cucurbitacin B, D, E, I, IIa, L glucoside, Q, and R with the most significant anticancer activity. They are reported to inhibit cell proliferation, invasion, and migration; induce apoptosis; and encourage cell cycle arrest, as some of their modes of action.

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L. is well known for its traditional medicinal properties as an anti-inflammatory, hepatoprotective, antifungal, antibacterial, antimutagenic, and wound healing agent. The aim of the present study was to determine antioxidant, genoprotective, and cytotoxic potential of different fractions of bark including hexane (CaMH), chloroform (CaMC), ethyl acetate (CaME), and methanol (CaMM).

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The limitations of prevailing probes for the detection of human serum albumin (HSA) and HSO make it challenging to apprehend the cooperative effect of both HSA and HSO in biological systems. Herein, we present a multi-responsive fluorescent probe , which distinguishes HSA from bovine serum albumin (BSA) through an ∼104-fold fluorescence enhancement at an emission maximum of 595 nm with HSA and only an ∼10-fold increase at an emission maximum of 615 nm with a shoulder at 680 nm with BSA. The absorbance spectrum of also discriminates HSA and BSA with the respective absorption maxima at 543 nm and at 580 nm.

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7-Methylxanthine (7-MX, CAS No. 552-62-5, purity 99.46%) is the first orally administered drug candidate, which showed anti-myopic activity in different pre-clinical studies.

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Here, in the present work, a new hydroxybenzothiazole derivative () with AIE+ESIPT features was synthesized by Suzuki-Miyora coupling of with 4-formylphenylboronic acid. The AIE and ESIPT features were confirmed by optical, microscopic (AFM) and dynamic light scattering (DLS) techniques. The yellow fluorescent aggregates of can specifically detect Cu/Cu ions with limits of detection as low as 250 nM and 69 nM.

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(.) is a genus of perennial flowering plants in the family Boraginaceae with approximately 250 species widely dispersed in temperate, tropical, and subtropical areas. It is traditionally used to treat rheumatism, fever, asthma, stomach irritation, and inflammatory ailments.

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The F ion and viscosity both affect the physiological state of mitochondria and to the best of our knowledge no fluorescent probe is reported for the dual detection of mitochondrial viscosity and F ion through different signals. DMAS-Si is weakly red fluorescent due to free intramolecular rotation between dimethylaminophenyl and pyridinium moieties and PET from silyloxy to the pyridinium moiety. In viscous medium (glycerol 90 %), the rotation is restricted and 18-fold increase in red-fluorescence (λ 637 nm) is observed.

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The present study aims to develop carboplatin injectable microspheres using spray-drying technology. The optimized powdered microspheres (MS-19-ST2) were morphologically spherical, with a 1.795 μm particle size and good micromeritic properties.

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ESIPT active PBI-keto/enol assemblies have been developed which show 'on-on' optical response towards 2,6-dichloro-4-nitroaniline (DCN) due to a combined ESIPT-AIEE phenomenon with a detection limit of 1.65 nM. The potential of PBI-keto/enol assemblies to detect DCN has also been explored in grape juice/grape residue and soil for six consecutive days.

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Positively charged amphiphiles hold great significance in supramolecular chemistry due to their good solubility, and physiochemical and molecular recognition properties. Herein, we report the synthesis, characterization and molecular recognition properties of the dicationic amphiphile based on perylene diimide-tyrosine alkyl amide amine (PDI 3). PDI 3 showed the formation of a nanoring architecture in the self-assembled aggregated state (90% HO-DMSO mixture) as observed by SEM and TEM studies.

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The current study was designed to assess the in vivo hepatoprotective properties of trans-Anethole, which is a principal aromatic component of star anise. The hepatoprotective effects of trans-Anethole were evaluated at three doses [40, 80, and 160 mg/kg body weight (b.wt.

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The current study was conducted to evaluate the antiproliferative and oxidative damage protection potential of endophytic fungi Aspergillus fumigatus and Chaetomium globosum isolated from Moringa oleifera. The chloroformic extract (CE) of both the fungi showed dose dependent antiproliferative activity against human prostate adenocarcinoma (PC-3) cell line with (IC) value of 0.055 mg/ml and 0.

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