Publications by authors named "Satu Poikola"
Background: Paracetamol-codeine combination tablet is widely used in pain management after day surgery. For safety reasons, its use has decreased in recent years. Codeine is a prodrug metabolised in the liver by the cytochrome P450 2D6 (CYP2D6) enzyme to morphine that produces the analgesic effect of codeine.
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- Researchers studied how different genetic variations in the CYP2D6 enzyme affect the body's ability to metabolize codeine into morphine, which is vital for determining pain relief and potential side effects.
- A clinical trial involving 1000 patients was conducted, where their CYP2D6 genotypes were analyzed after they were given a standard dose of codeine, and the relationship between their genetic makeup and morphine exposure was modeled.
- The results showed that individuals with certain genetic variations (like CYP2D6*10 and *41) had less effective metabolism of codeine, leading to significantly higher or lower morphine levels in the bloodstream, highlighting the importance of genetic testing for safer opioid prescribing.
Background: Subanesthetic ketamine may reduce perioperative consumption of opioids. We studied whether intravenous S-ketamine alters the pharmacokinetics of oral morphine in healthy volunteers.
Methods: In this paired, randomized, double-blind, crossover trial, 12 participants under a 2-hour intravenous S-ketamine (0.
Background: Several opioids are metabolized by the inducible cytochrome P450 (CYP) 3A isozymes. Coadministration with strong inducers of drug metabolism, such as rifampin, can dramatically reduce systemic exposure to these opioids. As the CYP metabolism of hydromorphone is of minor importance, we studied in healthy volunteers whether hydromorphone would be an effective analgesic for patients who concomitantly receive the prototypical enzyme inducer rifampin.
View Article and Find Full Text PDFBackground and aims Pain is the most common reason for delayed discharge after day-case laparoscopic cholecystectomy. This study investigates a simple five-item questionnaire in evaluating the risk of postoperative pain in day-case cholecystectomy and the efficacy and safety of single-dose preoperative pregabalin on patients with multiple risk factors for pain. There are no previous studies on targeting adjuvant pain treatment based on the individual risk factors like the preoperative state of anxiety, acute or chronic pain, and the expectation of pain in day-case surgery.
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