Epidemiology and Molecular Characterisation of Multidrug-Resistant Isolated from Cow Milk.

Antimicrobial resistance (AMR) is a growing global concern and poses a significant threat to public health. The emergence of multidrug-resistant organisms, including , also presents a risk of transmission to humans through the food chain, including milk. This study aimed to investigate the prevalence of in raw milk in the Chattogram metropolitan area (CMA) of Bangladesh and their phenotypic and genotypic antimicrobial resistance patterns.

A multi-phase structured cascade model for mass training of community healthcare workers in performing clinical breast exams in remote regions.

Background: Clinical breast exam (CBE) by outreach healthcare workers (HCW) may help downstage breast cancer in resource-limited areas where mammography may not be feasible. We evaluated the effectiveness of a pilot cascade-model training programme for HCWs in remote areas of Pakistan.

Methods: The training programme comprised three phases.

Amyotrophic lateral sclerosis diagnosis using machine learning and multi-omic data integration.

Amyotrophic Lateral Sclerosis (ALS) is a complex and rare neurodegenerative disorder characterized by significant genetic, molecular, and clinical heterogeneity. Despite numerous endeavors to discover the genetic factors underlying ALS, a significant number of these factors remain unknown. This knowledge gap highlights the necessity for personalized medicine approaches that can provide more comprehensive information for the purposes of diagnosis, prognosis, and treatment of ALS.

Assessment of online pharmacy applications in India by employing the mobile application rating scale.

Introduction: Over the past few years, the technology powering mobile devices such as smartphones has made significant progress. Furthermore, the healthcare industry is always progressing and actively embracing the latest technological advancements to achieve the highest level of efficiency. With the rising prevalence of smartphones and internet connection, customers are benefiting from reduced prices, convenient home delivery, and effortless accessibility through online pharmacies.

Combined bisoprolol and trimetazidine ameliorate arsenic trioxide -induced acute myocardial injury in rats: targeting PI3K/GSK-3β/Nrf2/HO-1 and NF-κB/iNOS signaling pathways, inflammatory mediators and apoptosis.

Background: Arsenic-trioxide (ATO) is an effective therapy for acute promyelocytic leukemia. Unfortunately, its utility is hindered by the risk of myocardial injury. Both bisoprolol (BIS) and trimetazidine (TMZ) have various pharmacological features, including anti-oxidant, anti-inflammatory, and anti-apoptotic properties.

Utilizing Stakeholder Consultations to Identify Context-Specific Professional Skills for Veterinary Graduates in Bangladesh.

Despite professional skills being part of the Day One Competences published by national as well as international accreditation bodies, veterinary schools in Bangladesh have limited associated teaching within their curricula. Therefore, our study aimed to identify the most important professional skills for veterinarians in Bangladesh through local consultation to inform future initiatives to change the curriculum. Eleven focus groups were conducted with 45 stakeholders who included veterinarians who supervise students on workplacements, faculty, recent graduates, final year students, and clients.

Comments on: prevalence and risk factors for tuberculosis and HIV coinfections in Kenyan prison inmates.

The study by Mwatenga et al. found a tuberculosis (TB) prevalence of 10.2% and an HIV prevalence of 19.

Brivaracetam and rufinamide combination increased seizure threshold and improved neurobehavioral deficits in corneal kindling model of epilepsy.

Background: Besides seizures, a myriad of overlapping neuropsychiatric and cognitive comorbidities occur in patients with epilepsy, which further debilitates their quality of life. This study provides an in-depth characterization of the impact of brivaracetam and rufinamide individually and in combination at 10 and 20 mg/kg doses, respectively, on corneal kindling-induced generalized seizures and behavioral alterations. Furthermore, observed convulsive frequency and behavioral changes were correlated to post-kindling-induced changes in the activity of markers of oxidative stress.

Ensembling methods for protein-ligand binding affinity prediction.

Protein-ligand binding affinity prediction is a key element of computer-aided drug discovery. Most of the existing deep learning methods for protein-ligand binding affinity prediction utilize single models and suffer from low accuracy and generalization capability. In this paper, we train 13 deep learning models from combinations of 5 input features.

Letter to the editor, "Superb microvascular ultrasound is a promising non-invasive diagnostic tool to assess a ventriculoperitoneal shunt system function: a feasibility study".

This letter discusses major aspects of the research "Superb Microvascular Ultrasound as a Promising Non-invasive Diagnostic Tool to Assess Ventriculoperitoneal Shunt System Function: A Feasibility Study." While the study shows great promise in adopting superb microvascular imaging (SMI) for non-invasive evaluation of ventriculoperitoneal shunt (VPS) systems, some limitations are noted. These include the small patient group, which focusses primarily on adult patients with programmable shunts, limiting the generalisability of the results.

Improvement of Vicia faba plant tolerance under salinity stress by the application of thiamine and pyridoxine vitamins.

Enhancement of plant growth at early growth stages is usually associated with the stimulation of various metabolic activities, which is reflected on morphological features and yield quantity and quality. Vitamins is considered as anatural plant metabolites which makes it a safe and ecofriendly treatment when used in appropriate doses, for that this research aimed to study the effect of two different vitamin B forms (thiamine and pyridoxine) on Vicia faba plants as agrowth stimutator in addition to study it's effect on plant as astrong antioxidant under salinity stress.Our findings demonstrated that both vitamin forms significantly increased seedling growth at germination and early growth stages, especially at 50 ppm for pyridoxine and 100 ppm for thiamine.

Transcriptomic and coexpression network analyses revealed the regulatory mechanism of infestation on the synthesis of phytohormones in walnut husks.

The codling moth () has a major effect on the quality and yield of walnut fruit. Plant defences respond to insect infestation by activating hormonal signalling and the flavonoid biosynthetic pathway. However, little is known about the role of walnut husk hormones and flavonoid biosynthesis in response to infestation.

The accuracy and precision of plain CT chest for diagnosis of anaemia.

Objective: To determine the accuracy and precision of anaemia diagnosis with plain computed tomography of chest by keeping complete blood count as the gold standard.

Methods: The cohort study was conducted from January 1 to December 31, 2020, at Dow University of Health Sciences, Karachi, and comprised patients attending the hospital regardless of gender or age. The subjects underwent complete blood count and high-resolution computed tomography scan of chest with 7-day interval.

An Opioid-Sparing Pain Protocol of Intravenous and Oral Ketorolac Reduces Opioid Consumption and Pain Levels After Arthroscopic Meniscus Surgery: A Prospective, Randomized Controlled Trial.

Background: The primary purpose was to compare ketorolac to oxycodone-acetaminophen with respect to pain and opioid consumption after arthroscopic meniscus surgery. The secondary purpose was to compare short-term functional outcomes between the 2 protocols.

Methods: A power analysis demonstrated that 43 patients were required.

Accuracy and Comparison of Core Needle Biopsy Diagnoses With Excision Specimen for Diagnosing Fibroepithelial Lesions of the Breast.

Background Core needle biopsy (CNB) for fibroepithelial lesions (FELs) of the breast is commonly encountered by histopathologists. The distinction between fibroadenoma (FA) and phyllodes tumor (PT) can be challenging due to overlapping histological features and the limited nature of CNB material.  Objective This study aimed to assess the accuracy of CNB diagnosis of FA and PT by comparing it with a diagnosis on subsequent surgical excision specimen.

Association of Endoplasmic Reticulum Aminopeptidase 1 Gene Polymorphism with Susceptibility and Severity of Axial Spondyloarthritis in Egyptian Population: A Single-center Case-Control Study.

Background: Axial spondyloarthritis (axSpA) is a systemic, progressive, autoimmune disease. Complex interactions between environmental factors and host immune responses are the origin of axSpA. Together with human leukocyte antigen (HLA-B27), endoplasmic reticulum aminopeptidase 1 (ERAP1) gene is a potential non-HLA contributor to axSpA susceptibility.

Valuation of knowledge, attitude, practices of tuberculosis among the health care workers from Islamabad Pakistan.

Background: Tuberculosis (TB) as a foremost infectious disease adds massive burden to morbidity and mortality rate, despite of well-structured TB control programs around the globe. Inappropriate health care management system and poor implementation on standard in relevance to TB, remain some reasons causative to TB prevalence and its rising antimicrobial resistance. Health Care Workers (HCWs) laboring as a part of TB control system, are the vital warriors in achieving the goals of TB End Strategy by 2035.

Comprehensive Analysis of Curcumin Zinc Oxide Nanoparticles, Synthesis, Characterization, and Cytogenotoxic Profiling.

Curcumin from turmeric () has traditionally been used due to its pharmacological properties, such as anticancer, anti-inflammatory, cholesterol-lowering, and antioxidant activities, but has had limitations in use due to low bioavailability. Nanoparticles have protuberant efficacies to diagnose or cure a variety of diseases, including tumors, by fine-tuning their size, structure, and physicochemical characteristics. This study aims to develop a new dosage form of curcumin nanoparticles with zinc oxide to enhance its therapeutic efficacy against cancer and cause no damage to genetics.

Perceptual Effects of Walnut Volatiles on the Codling Moth.

The volatile organic compounds (VOCs) of plant hosts allow insect localization through olfactory recognition. In this study, the oviposition behavior of the codling moth was investigated and the VOCs from different walnut organs were extracted and analyzed to systematically study their composition and content differences. The electrophysiological and behavioral responses of the codling moth to walnut VOCs were measured using gas chromatography-electroantennographic detection (GC-EAD) and a four-arm olfactometer to screen the key active contents.