Publications by authors named "Satsuki Kakiuchi"

Objectives: To elucidate the outcomes of periviable infants receiving active care (AC) and explore perinatal factors associated with neurodevelopmental outcomes.

Methods: This is a single-center retrospective study on infants born at 22-25 weeks of gestation, all of whom received AC. A developmental quotient (DQ) ≥ 85 at corrected 18 months was judged as normal.

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  • Congenital cytomegalovirus (cCMV) infection is the most prevalent congenital infection in developed nations, and while there’s no established standard therapy yet, management evidence is growing.
  • The first edition of the "Clinical Practice Guidelines for the Management of Congenital Cytomegalovirus Infection" was published in Japan in 2023, outlining key clinical questions related to cCMV.
  • The guidelines cover 20 clinical questions on aspects like prenatal risk assessment, diagnosis, treatment, and follow-up, along with recommendations and consensus rates to aid healthcare providers in managing cCMV patients.
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Meconium, a non-invasive biomaterial reflecting prenatal substance accumulation, could provide valuable insights into neonatal health. However, the comprehensive protein profile of meconium across gestational ages remains unclear. Here, we conducted an extensive proteomic analysis of first meconium from 259 newborns across varied gestational ages to delineate protein composition and elucidate its relevance to neonatal diseases.

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The binding ratio of palmitic acid (PA) at the sn-2 position of triacylglycerols in infant formulas is lower than that in breast milk, resulting in higher levels of fecal PA. Even if the ratio is increased to 40-50%, fecal PA levels in formula-fed infants remain higher than those in breast-fed infants. In Japan, infant formulas with 50% or more of PA bound to sn-2 (high sn-2 PA milk) are commercially available; however, their effects on PA excretion have not been investigated.

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The 22q11.2 deletion syndrome has many complications; one of them is immunodeficiency. However, the time of onset and the degree of immunodeficiency can vary.

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Background: Intravenous immunoglobulin G (IVIG) is used to treat blood-type incompatibility hemolytic disease of newborns (BTHDN). Although IVIG's efficacy for treating BTHDN has been challenged, as an updated systematic review suggests, IVIG could significantly reduce exchange transfusions. We conducted a mail-in questionnaire survey to ascertain actual use of IVIG for BTHDN in Japan.

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  • This study evaluated the impact of adding biotin to infant formula on biotin metabolism and overall development in Japanese infants.
  • 84 healthy infants were divided into two groups, receiving either low-biotin (Formula A) or high-biotin (Formula B) formula, with a follow-up extending until they reached 36 months of age.
  • Results showed that Formula B significantly increased urinary biotin levels at both 1 and 6 months compared to Formula A and breast milk, leading to a recommendation for biotin in infant formula by Japan's government in 2014.
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Reports on the birth of infants weighing <300 g are quite rare and little is known about the best practices in treating such micropreemies. Therefore, we report here on three cases of low birthweight infants weighing <300 g, of whom two infants survived. The birthweights and gestational ages were ranging 279-293 g and 22 + 6/7 - 23 + 6/7 weeks, respectively.

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Pulmonary hypoplasia is a rare entity in a fetus with imperforate anus. The fetus was diagnosed with high-type imperforate anus with rectourethral fistula based on the dilated fetal bowel and the presence of bowel calcification at 19 weeks of gestation. As gestation advanced, fetal ultrasonography demonstrated development of pulmonary hypoplasia, progressive bowel dilation, and persistent oligohydramnios from 28 weeks of gestation despite a fluid-filled bladder without hydroureter or hydronephrosis.

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Neonatal disseminated herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity; yet, the pathophysiology remains unclear. Here, we report a male infant with disseminated HSV type 1 (HSV-1) infection, complicated by hemophagocytic lymphohistiocytosis (HLH) and multiple organ failure. The infant, born at 39 weeks of gestation by normal delivery, developed fever (38.

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  • A comprehensive study examined respiratory viral infections (RVIs) in patients undergoing hematopoietic stem cell transplantation (HSCT) through the collection of oropharyngeal swabs over a 2-year period.
  • Out of 250 patients, 79 were found to have RVIs, with the parainfluenza virus type 3 (PIV3) being the most common, accounting for 71% of the cases.
  • The study highlights the importance of monitoring RVIs in HSCT wards, as asymptomatic PIV3 infections can occur and are linked to more severe respiratory complications.
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In Japan, indigenous tick-borne phleboviruses (TBPVs) and their associated diseases first became evident in 2013 by reported human cases of severe fever with thrombocytopenia syndrome (SFTS). In this study, we report a novel member of the genus Phlebovirus designated as Kabuto Mountain virus (KAMV), which was isolated from the ixodid tick Haemaphysalis flava in Hyogo, Japan. A complete viral genome sequencing and phylogenetic analyses showed that KAMV is a novel member of TBPVs, which is closely related to the Uukuniemi and Kaisodi group viruses.

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  • Ion Torrent next-generation sequencing (NGS) technology was used to study how acyclovir-resistant herpes simplex virus type 1 (HSV-1) develops in patients who had hematopoietic stem cell transplants.
  • The NGS method not only confirmed all mutations found through traditional Sanger sequencing but also detected additional mutations that confer resistance to acyclovir.
  • This new approach provides a more detailed understanding of the emergence of these mutations and allows for earlier diagnosis of acyclovir-resistant HSV-1 infections compared to the traditional sequencing method.
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  • Antiviral-resistant herpes simplex virus type 1 (HSV-1) is becoming a significant issue for patients undergoing hematopoietic stem cell transplantation (HSCT).
  • A study found that 15% of HSCT patients tested positive for HSV-1 within 100 days post-transplant, and 28% of those had acyclovir-resistant HSV-1.
  • The presence of either HSV-1 or its resistant form was linked to higher mortality rates, particularly in patients with relapsed malignancies, highlighting the need for careful monitoring and management of HSV-1 in HSCT patients.
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Potency controls of inactivated rabies vaccines for human use are confirmed by the National Institutes of Health challenge test in which lethal infection with severe neurological symptoms should be observed in approximately half of the mice inoculated with the rabies virus. Weight loss, decreased body temperature, and the presence of rabies-associated neurological signs have been proposed as humane endpoints. The potential for reduction of animal suffering by introducing humane endpoints in the potency test for inactivated rabies vaccine for human use was investigated.

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Tetraploidy is characterized by the presence of four complete sets of chromosomes in an individual. Full tetraploidy is usually considered lethal. To date, only ten live-births with the condition have been reported.

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  • Researchers have identified a new tick-borne orbivirus from Ixodes turdus ticks in Japan, naming it Muko virus (MUV), which is part of the Great Island virus species.
  • MUV was found to replicate in various cell lines and caused high mortality in suckling mice when injected.
  • The full genome analysis reveals that MUV shares significant similarities with Tribeč virus, contributing to the understanding of genetic diversity and evolution within the Great Island virus species.
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Rabies is a viral disease transmitted through bites from rabid animals and can be prevented by vaccines. Clinically used rabies vaccines are prepared from inactivated rabies viruses grown in cell cultures or embryonated eggs. In Japan and across the world, tests that confirm complete inactivation, such as the in vivo suckling mouse assay, in which suckling mice are intracerebrally inoculated with vaccine products, are required for quality control.

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Acyclovir (ACV)-resistant (ACV(r)) mutants were generated from plaque-purified ACV-sensitive herpes simplex virus type 1 (HSV-1) by culturing the virus in Vero cells in the presence of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl) purine (S2242). Three DNA polymerase (DNApol)-associated ACV(r) HSV-1 generated under ACV selection in a previous study (Suzutani, T., Ishioka, K.

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A neonate with herpes simplex virus 1 encephalitis was treated with intravenous acyclovir. During the course of therapy, the infection became intractable to the treatment and a mutation in the viral thymidine kinase gene (nucleotide G375T, amino acid Q125H) developed. This mutation was demonstrated in vitro to confer acyclovir resistance.

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