Publications by authors named "Satsuki Ieda"
Article Synopsis
- Progressive familial intrahepatic cholestasis (PFIC) is a serious liver disease in children that can lead to the need for liver transplantation and is linked to mutations in the ABCB4 gene, which is important for bile production.
- Mice lacking the Abcb4 gene (Abcb4-deficient mice) typically display milder symptoms than humans due to the presence of less harmful bile acids, but researchers created CYPDKO mice with a more human-like bile acid profile to improve disease modeling.
- By inducing the Abcb4 deletion in CYPDKO mice, researchers found these animals experienced more severe liver injury and inflammation, making them a better model for studying PFIC and
Objective: Hepatitis C virus (HCV) was identified in 1989. In 2020, three decades after HCV identification, three researchers won the Nobel Prize in Physiology or Medicine for the discovery of this virus. In 1992, three years after the discovery, interferon (IFN) was launched as the first anti-HCV therapy in Japan; however, the efficacy of IFN therapy was far from acceptable due to severe adverse effects.
View Article and Find Full Text PDFBackground: Many studies have investigated the prognosis of nonalcoholic fatty liver disease (NAFLD); however, most studies had a relatively short follow-up. To elucidate the long-term outcome of NAFLD, we conducted a retrospective cohort study of patients with biopsy-proven NAFLD.
Methods: We re-evaluated 6080 patients who underwent liver biopsy from 1975 to 2012 and identified NAFLD patients without other etiologies.
European studies have revealed that the ABCB11 c.1331T>C (V444A) polymorphism (rs2287622) C-allele frequency is higher among patients with drug-induced cholestasis. Given the low incidence of this disease, however, this association has not been sufficiently elucidated.
View Article and Find Full Text PDFObjective: Microinjectin of neostigmine, an inhibitor of acetylcholine esterase, into the rat hippocampus elicited stress-like responses reflected by the release of adrenocorticotropic hormone (ACTH) and blood glucose elevations. The entorhinal cortex is regarded as an interface between the hippocampus and neocortex. The current study was designed to examine the role of the entorhinal cortex in regulation of blood glucose elevation induced by hippocampal neostigmine injection.
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