Publications by authors named "Satsuki Aochi"
Objective: To identify genes that could provide clues leading to the discovery of drugs to treat IgG4-related disease (IgG4-RD).
Methods: Submandibular gland tissue bulk RNAseq analysis of 45 cases with a definite diagnosis of IgG4-RD was integrated with Visium spatial transcriptome analysis of 2 cases to identify pathogenic genes expressed in tertiary lymphoid tissues.
Results: Bulk RNAseq and pathway analyses showed upregulation of cell cycle and T cell-related signals in IgG4-RD.
Glucocorticoids (GC) are the standard of care for the induction and maintenance of remission in immunoglobulin G4 (IgG4)-related diseases. However, IgG4-related diseases often relapse with GC dose reduction, not only making GC dose reduction difficult but also necessitating GC dose escalation in many cases. Therefore, other immunosuppressive drugs are required to maintain remission.
View Article and Find Full Text PDFObjectives: To identify the specific microRNAs (miRNAs) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS) and predict the targeted genes.
Methods: miRNAs in the serum of nine patients with IgG4-DS, three patients with primary Sjögren's syndrome, and three healthy controls were analysed using the human miRNA chip, and miRNAs that exhibited significant fluctuation in expression in IgG4-DS patients were extracted. The respective target genes were predicted using an existing database, and expression of the target genes was evaluated in actual submandibular gland tissues affected by IgG4-DS.
Objective Glucocorticoids are key drugs used in remission induction therapy for IgG4-related disease (IgG4-RD). However, the therapeutic outcomes vary widely, with some patients requiring long-term maintenance therapy and others relapsing repeatedly, whereas still others can tolerate withdrawal. These variations underscore the need for personalized treatment strategies for IgG4-RD.
View Article and Find Full Text PDFObjectives: This article aims to investigate the saliva microbiome in patients with immunoglobulin G4-related disease (IgG4RD) compared with primary Sjögren's syndrome (SS).
Methods: Saliva samples were collected from 11 IgG4RD and 11 SS patients who visited IMSUT Hospital, The Institute of Medical Science, The University of Tokyo. Deoxyribonucleic acid (DNA) was extracted from the samples, and primers were used to amplify the V3-V4 regions of bacterial and archaeal 16S ribosomal RNA (rRNA) genes, which was then analysed by paired-end sequencing.
A 78-year-old Japanese woman with no history of rheumatic disease received 2 doses of the BNT162b2 COVID-19 mRNA vaccine. Two weeks later, she noticed bilateral swelling in the submandibular region. Blood tests showed hyper-immunoglobulin (Ig)G4emia, and F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) revealed the strong accumulation of FDG in the enlarged pancreas.
View Article and Find Full Text PDFArticle Synopsis
- Tumor necrotic factor (TNF) inhibitors, like adalimumab (ADA), can trigger lupus and related conditions in patients, as seen in a case involving a Crohn's disease patient.
- The patient developed positive anti-DNA and antiphospholipid antibodies, leading to a pulmonary embolism, but early diagnosis and treatment helped her recover without needing steroids.
- It's crucial to monitor for symptoms of antiphospholipid syndrome in patients taking TNF inhibitors and to act quickly by withdrawing the medication and administering anticoagulants when necessary.
Article Synopsis
- The study focuses on using artificial intelligence to improve the diagnosis of IgG4-related disease (IgG4-RD), a rare and complex condition that requires specialized knowledge.
- Researchers collected data from 602 patients diagnosed with IgG4-RD and 204 patients with other conditions, applying machine learning techniques like decision trees and random forests to distinguish between them.
- Results showed high accuracy in classifying IgG4-RD using patient characteristics and blood test results, achieving AUROC curve values of 0.974 when including serum IgG4 levels, indicating that AI can help reduce disparities in diagnosing rare diseases.
A 40-year-old man was admitted to our hospital for COVID-19. He had been treated for essential thrombocythemia (ET). He was diagnosed severe illness of COVID-19, oxygen therapy and dexamethasone were administered.
View Article and Find Full Text PDFImmunoglobulin (Ig) G4-related disease (IgG4-RD) is often complicated by allergic disorders. This study was conducted to investigate the mechanism of type 2 helper T-inflammation (Th2-inflammation) in IgG4-related dacryoadenitis and sialadenitis (IgG4-DS). We separated and analyzed the proportion of growth stimulation expressed gene 2 (ST2) memory Th2 cells among the peripheral blood mononuclear cells by flow cytometry in cases with IgG4-DS and healthy individuals.
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