Quantitative assessment of Tc-methylene diphosphonate bone SPECT/CT for assessing bone metastatic burden and its prognostic value in patients with castration-resistant prostate cancers: initial results in a single-center retrospective study.

Purpose: To evaluate the prognostic value of the quantitative assessment of Tc-methylene diphosphonate (Tc-MDP) bone SPECT/CT in castration-resistant prostate cancer (CRPC) patients with bone metastases.

Methods: A total of 103 patients who underwent Tc-MDP bone SPECT/CT imaging from the neck to the proximal femur were included. First, in 65 patients without bone metastases, the normal range of standardized uptake value (SUV) of non-pathological bone was evaluated to determine an SUV threshold to reliably exclude most normal osseous activity.